Results 151 to 160 of about 4,105,290 (355)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

MULTIPLEX TISSUE ANALYSIS OF NEURONAL LINEAGE MARKERS IN DEVELOPING MOUSE BRAIN

IBRO Neuroscience Reports, 2023
Eugenia Kuteeva, Mikael Malmqvist
doaj   +1 more source

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Nature, 2018
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal ...
Pilar Mendoza, H. Gruell, Lilian Nogueira, J. Pai, Allison L. Butler, Katrina G. Millard, C. Lehmann, I. Suárez, Thiago Y. Oliveira, J. C. Lorenzi, Yehuda Z. Cohen, C. Wyen, T. Kümmerle, Theodora Karagounis, Ching-Lan Lu, L. Handl, Cecilia Unson-O’Brien, R. Patel, Carola Ruping, M. Schlotz, M. Witmer-Pack, I. Shimeliovich, G. Kremer, E. Thomas, K. Seaton, Jill Horowitz, A. West, P. Bjorkman, G. Tomaras, R. Gulick, N. Pfeifer, G. Fätkenheuer, M. Seaman, F. Klein, M. Caskey, M. Nussenzweig   +35 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Human neutralizing antibodies elicited by SARS-CoV-2 infection

Nature, 2020
B. Ju, Qi Zhang, J. Ge, Ruoke Wang, Jing Sun, X. Ge, Jiazheng Yu, S. Shan, Bingjie Zhou, Shuo Song, Xianchun Tang, Jinfang Yu, J. Lan, Jing Yuan, Haiyan Wang, Juanjuan Zhao, Shuye Zhang, Youchun Wang, Xuanling Shi, Lei Liu, Jincun Zhao, Xinquan Wang, Zheng Zhang, Linqi Zhang   +23 more
semanticscholar   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Development of novel monoclonal antibodies for blocking NF-κB activation induced by CD2v protein in African swine fever virus

Frontiers in Immunology
BackgroundCD2v, a critical outer envelope glycoprotein of the African swine fever virus (ASFV), plays a central role in the hemadsorption phenomenon during ASFV infection and is recognized as an essential immunoprotective protein.
Rongrong Fan, Rongrong Fan, Zeliang Wei, Zeliang Wei, Zeliang Wei, Mengmeng Zhang, Shanshan Jia, Zhiyang Jiang, Yao Wang, Junyu Cai, Junyu Cai, Guojiang Chen, He Xiao, Yinxiang Wei, Yanchun Shi, Jiannan Feng, Beifen Shen, Yuanqiang Zheng, Yaojiang Huang, Jing Wang   +19 more
doaj   +1 more source

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Nature, 2020
Lihong Liu, Pengfei Wang, M. Nair, Jian Yu, M. Rapp, Qian Wang, Yang Luo, J. Chan, V. Sahi, A. Figueroa, Xinzheng V. Guo, G. Cerutti, Jude S. Bimela, J. Gorman, T. Zhou, Zhiwei Chen, K. Yuen, P. Kwong, J. Sodroski, M. Yin, Zizhang Sheng, Yaoxing Huang, L. Shapiro, D. Ho   +23 more
semanticscholar   +1 more source