Results 161 to 170 of about 3,219,836 (309)

Characterization of antibodies against the replication protein (Rep) encoded by bovine meat and milk factors (BMMFs). [PDF]

Appl Microbiol Biotechnol
Frehtman V, Shukla G, Gentz M, Müller M, Duduyemi OP, Grewe I, Ernst C, Tessmer C, Didier A, Hofmann I, Bund T, Leuchs B.   +11 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Alternative diagnoses in patients referred to neuroimmunology for autoimmune encephalitis evaluation. [PDF]

J Neurol
Damman SF, Rai SM, Shrestha R, Shaikh AG, Abboud H.   +4 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues. [PDF]

J Neurochem
de Las Casas M, Hernández-Ortego P, Torres-Montero R, De la Peña E, Gomis A, Viana F, Fernández-Trillo J.   +6 more
europepmc   +1 more source

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Autoantibodies in the follow-up of autoimmune hepatitis. [PDF]

J Transl Autoimmun
Nagy G, Bencze D, Demeter S, Pénzes-Daku K, Szabó L, Tóth B, Földesi R, Papp M, Antal-Szalmás P.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Hypoglycemia in diabetes with low-affinity insulin antibody successfully improved by treating sleep apnea syndrome. [PDF]

JCEM Case Rep
Tanaka K, Nakano Y, Goto H, Okumura M, Takeshita Y, Takamura T.   +5 more
europepmc   +1 more source