Results 251 to 260 of about 3,219,836 (309)
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Phage antibodies: will new ‘coliclonal’ antibodies replace monoclonal antibodies?
Trends in Biotechnology, 1992Antibodies can now be rapidly isolated from large and diverse recombinant libraries by displaying functional antibody fragments on the surface of bacteriophage particles and directly selecting with antigen. This method has been used to isolate antibodies, including human antibodies, with and without immunization, and to improve the affinity and ...
D J, Chiswell, J, McCafferty
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International Reviews of Immunology, 1993
One of the major advantages of genetic engineering is the ability to produce novel, hybrid antibodies. Hybrid antibodies can be assembled using fragments from different antibodies with the objective of assembling novel combinations of antibody-related effector functions.
S U, Shin, A, Wright, S L, Morrison
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One of the major advantages of genetic engineering is the ability to produce novel, hybrid antibodies. Hybrid antibodies can be assembled using fragments from different antibodies with the objective of assembling novel combinations of antibody-related effector functions.
S U, Shin, A, Wright, S L, Morrison
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Journal of Infectious Diseases, 1981
Serologic reagents have played an important role in the diagnosis, treatment, and epidemiology of infectious diseases. A new technology has been developed for generating homogeneous antibodies that can be produced in large amounts and are available indefinitely. This technique promises to increase the reliability and sensitivity of immunoassays and may
M D, Scharff, S, Roberts, P, Thammana
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Serologic reagents have played an important role in the diagnosis, treatment, and epidemiology of infectious diseases. A new technology has been developed for generating homogeneous antibodies that can be produced in large amounts and are available indefinitely. This technique promises to increase the reliability and sensitivity of immunoassays and may
M D, Scharff, S, Roberts, P, Thammana
openaire +4 more sources
Science, 1986
Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These substrates are distinguished by the structural congruence of both hydrolysis products with haptenic fragments.
A, Tramontano, K D, Janda, R A, Lerner
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Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These substrates are distinguished by the structural congruence of both hydrolysis products with haptenic fragments.
A, Tramontano, K D, Janda, R A, Lerner
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Trends in Pharmacological Sciences, 1993
Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering, reviewed her by Greg Winter and William Harris, is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies ...
G, Winter, W J, Harris
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Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering, reviewed her by Greg Winter and William Harris, is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies ...
G, Winter, W J, Harris
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Reumatología Clínica (English Edition), 2010
Anti-nuclear antibodies (ANA) are immunoglobulin directed against autologous cell nuclear and cytoplasmic components. Besides the autoimmune ANA there are other ANA that can be detected in circulation, like natural and infectious ANA. Because of its high sensibility, detection of the ANA must be done by indirect immunofluorescence (IIF) as screening ...
Javier, Cabiedes +1 more
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Anti-nuclear antibodies (ANA) are immunoglobulin directed against autologous cell nuclear and cytoplasmic components. Besides the autoimmune ANA there are other ANA that can be detected in circulation, like natural and infectious ANA. Because of its high sensibility, detection of the ANA must be done by indirect immunofluorescence (IIF) as screening ...
Javier, Cabiedes +1 more
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Nature, 1992
A new process, antigenization of antibodies, consisting of the expression of oligopeptides in the hypervariable loops of an antibody molecule is described. The potential applications of antigenized antibodies are discussed.
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A new process, antigenization of antibodies, consisting of the expression of oligopeptides in the hypervariable loops of an antibody molecule is described. The potential applications of antigenized antibodies are discussed.
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Current Opinion in Structural Biology, 1998
Among the most important advances in antibody engineering of this past year is the advent of new tools to study the relationship between protein (including antibody) structure and function. Very rapid large-scale mutational analysis of antibodies is now possible by using in vitro transcription and translation.
W, Dall'Acqua, P, Carter
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Among the most important advances in antibody engineering of this past year is the advent of new tools to study the relationship between protein (including antibody) structure and function. Very rapid large-scale mutational analysis of antibodies is now possible by using in vitro transcription and translation.
W, Dall'Acqua, P, Carter
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Clinics in Laboratory Medicine, 1996
The proper diagnosis of patients with immune-mediated thrombocytopenias can be accomplished by using the advances made in the field of platelet serology. These techniques range from solid phase red cell adherence to sequencing platelet antigen amino acids by polymerase chain reaction.
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The proper diagnosis of patients with immune-mediated thrombocytopenias can be accomplished by using the advances made in the field of platelet serology. These techniques range from solid phase red cell adherence to sequencing platelet antigen amino acids by polymerase chain reaction.
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2013
Here we describe a detailed protocol for the one-step preparation of antigen-specific human chimeric immunoglobulin G (IgG) monoclonal antibodies (mAbs) using an in vitro antibody design method referred to as the ADLib (Autonomously Diversifying Library) system.
Kohei, Kurosawa +2 more
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Here we describe a detailed protocol for the one-step preparation of antigen-specific human chimeric immunoglobulin G (IgG) monoclonal antibodies (mAbs) using an in vitro antibody design method referred to as the ADLib (Autonomously Diversifying Library) system.
Kohei, Kurosawa +2 more
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