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Antibody and antibody derivatives as cancer therapeutics
WIREs Nanomedicine and Nanobiotechnology, 2019Antibodies are an important class of therapeutic for treating a wide range of diseases. These versatile macromolecules can be engineered to target many different antigens and to utilize several mechanisms of action to produce a pharmacological effect. The most common antibody platform used for therapeutics is immunoglobulin G (IgG). Advances in protein‐
Keith J, Arlotta, Shawn C, Owen
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Production of antibodies and antibody fragments in plants
Vaccine, 2001Our current knowledge allows the generation of transgenic plants that efficiently produce heterologous proteins from plant, bacterial, fungal or animal origin. Among all types of recombinant proteins, antibodies are particularly attractive because of their ability to specifically recognize and bind virtually any type of antigen.
Peeters, Koen +4 more
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Antiacetylcholinesterase antibodies: Enzyme antibodies interaction
Pharmacological Research Communications, 1981Summary Erythrocyte acetylcholinesterase activity of rabbits was significantly increased over control levels by immunization with acetylcholinesterase from the electric organ of the electric eel. The increase of enzyme activity and that of anti-acetylcholinesterase antibodies had the same time course, reaching a maximum level on the 35th day.
D, Pedretti +3 more
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Antiphospholipid antibodies and the antiphospholipid antibody syndrome
Drugs of Today, 2000The antiphospholipid antibody syndrome is a multisystem disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia and recurrent spontaneous abortion. Anticardiolipin antibodies and the lupus anticoagulant are different classes of antiphospholipid antibodies associated with this ...
G T, Nahass, S L, Jensen
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Veterinary Microbiology, 2006
Herpesviruses have developed different tools to thwart efficient antibody-dependent neutralisation and lysis of virions and elimination of infected cells. This overview will briefly summarize different of these tools, including (i) viral Fc receptors and the resulting process of antibody bridging, (ii) internalization of individual viral proteins and ...
Herman W, Favoreel +4 more
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Herpesviruses have developed different tools to thwart efficient antibody-dependent neutralisation and lysis of virions and elimination of infected cells. This overview will briefly summarize different of these tools, including (i) viral Fc receptors and the resulting process of antibody bridging, (ii) internalization of individual viral proteins and ...
Herman W, Favoreel +4 more
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Antibody Suppression and Antiallotype Antibodies
Scandinavian Journal of Immunology, 1976Antibody formation in rabbits against sheep erythrocytel (SRBC) was suppressed after injection of anti‐SRBC IgG. Suppression did not occur, however, if the injected IgG had an allotypic marker to which the rabbits possessed circulating antibody.
D, Jerne, B, Aasted
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Antiphospholipid antibody and antiphospholipid antibody syndrome
Current Opinion in Rheumatology, 1991New details have been added to the description of the antiphospholipid antibody syndrome. These include quantitation of risk of stroke; delineation of an associated acute occlusive vasculopathy syndrome, including its pathology; increased awareness of the association of adrenal insufficiency with antiphospholipid antibody; new demonstration of ...
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Advanced Drug Delivery Reviews, 2006
The clinical and commercial success of monoclonal antibodies has led to the need for very large-scale production in mammalian cell culture. This has resulted in rapid expansion of global manufacturing capacity [1], an increase in size of reactors (up to 20,000 L) and a greatly increased effort to improve process efficiency with concomitant ...
John R, Birch, Andrew J, Racher
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The clinical and commercial success of monoclonal antibodies has led to the need for very large-scale production in mammalian cell culture. This has resulted in rapid expansion of global manufacturing capacity [1], an increase in size of reactors (up to 20,000 L) and a greatly increased effort to improve process efficiency with concomitant ...
John R, Birch, Andrew J, Racher
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Recombinant Antibodies for the Generation of Antibody Arrays
2011Affinity proteomics, mainly represented by antibody microarrays, has in recent years been established as a powerful tool for high-throughput (disease) proteomics. The technology can be used to generate detailed protein expression profiles, or protein maps, of focused set of proteins in crude proteomes and potentially even high-resolution portraits of ...
Carl A K, Borrebaeck, Christer, Wingren
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From antibodies to sperm to antibodies in transplantation
Urology, 1998a) To assess the use of "panning" procedures for the detection of antibodies to sperm. b) To develop and use human monoclonal antibodies for the analysis of human transplantation antigens."Panning" assays were developed. The procedures and their use in the analysis of mouse monoclonal antibodies to human sperm are described.
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