Results 281 to 290 of about 4,329,929 (348)
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Antibody and antibody fragments for cancer immunotherapy
Journal of Controlled Release, 2020Antibody has become the most rapidly expanding class of pharmaceuticals for treating a wide variety of human diseases including cancers. Especially, with the fast development of cancer immunotherapy, antibody drugs have become the most promising therapeutic for curing cancers.
Weizhi Chen, Yang Yuan, Xiqun Jiang
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Phage antibodies: will new ‘coliclonal’ antibodies replace monoclonal antibodies?
Trends in Biotechnology, 1992Antibodies can now be rapidly isolated from large and diverse recombinant libraries by displaying functional antibody fragments on the surface of bacteriophage particles and directly selecting with antigen. This method has been used to isolate antibodies, including human antibodies, with and without immunization, and to improve the affinity and ...
D J, Chiswell, J, McCafferty
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Antibodies in proteomics I: generating antibodies
Trends in Biotechnology, 2003The explosion in genome sequencing, and in subsequent DNA array experiments, has provided extensive information on gene sequence, organization and expression. This has resulted in a desire to perform similarly broad experiments on all the proteins encoded by a genome.
BRADBURY A. +9 more
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Monoclonal Antibodies, Bispecific Antibodies and Antibody-Drug Conjugates in Oncohematology
Recent Patents on Anti-Cancer Drug Discovery, 2020Background: The therapeutic outcomes and the prognosis of patients with various hematologic malignancies are not always ideal with the current standard of care. Objective: The aim of this study is to analyze the results of the use of monoclonal antibodies, bispecific antibodies and antibody-drug conjugates for the therapy of malignant hemopathies.
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Journal of Immunology, 1972
A sensitive and simple method for the quantitative determination of antibodies is reported. Tubes coated with antigen are incubated with antiserum followed by an enzyme-labeled preparation of anti-immunoglobulin. The enzyme remaining in the tubes after
E. Engvall, P. Perlmann
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A sensitive and simple method for the quantitative determination of antibodies is reported. Tubes coated with antigen are incubated with antiserum followed by an enzyme-labeled preparation of anti-immunoglobulin. The enzyme remaining in the tubes after
E. Engvall, P. Perlmann
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Antibody and antibody derivatives as cancer therapeutics
WIREs Nanomedicine and Nanobiotechnology, 2019Antibodies are an important class of therapeutic for treating a wide range of diseases. These versatile macromolecules can be engineered to target many different antigens and to utilize several mechanisms of action to produce a pharmacological effect. The most common antibody platform used for therapeutics is immunoglobulin G (IgG). Advances in protein‐
Keith J, Arlotta, Shawn C, Owen
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Antiphospholipid antibody and antiphospholipid antibody syndrome
Current Opinion in Rheumatology, 1991New details have been added to the description of the antiphospholipid antibody syndrome. These include quantitation of risk of stroke; delineation of an associated acute occlusive vasculopathy syndrome, including its pathology; increased awareness of the association of adrenal insufficiency with antiphospholipid antibody; new demonstration of ...
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Journal of Clinical Endocrinology and Metabolism, 2002
J. Hollowell +6 more
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J. Hollowell +6 more
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
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