Results 21 to 30 of about 2,398,753 (259)

A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults. [PDF]

, 2010
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa.
Zijlstra, EE, Molyneux, Malcolm E, White, Sarah A., Mwaiponya, Martin, Mwalukomo, Thandie, Gordon, Stephen, Zijlstra, Eduard E, Longwe, Herbert, French, N, Mwalukomo, T, White, SA, French, Neil, Gordon, SB, Mwaiponya, M, Gilks, CF, Gilks, Charles F, Mwafulirwa, Gershom, Molyneux, Malcolm E., Mwafulirwa, G, Molyneux, ME, Gordon, Stephen B., Gordon, Stephen B, White, Sarah; id_orcid, Longwe, H, Gilks, Charles F., White, Sarah A, Zijlstra, Eduard E.   +26 more
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Antibody–siRNA conjugates (ARC): Emerging siRNA drug formulation

Medicine in Drug Discovery, 2022
Antibody–drug conjugates (ADC) utilizing the targeting properties of antibodies and therapeutic effects of drugs have emerged a rapid development in recent years.
Weiran Cao, Rui Li, Xing Pei, Meihong Chai, Lu Sun, Yuanyu Huang, Jiancheng Wang, Stefan Barth, Fei Yu, Huining He   +9 more
doaj   +1 more source

Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates

Nature Communications, 2020
Antibody-drug conjugates targeting high expression receptors can suffer from poor tumour penetration. Here, the authors use unconjugated antibody to improve the penetration of an antibody-dye conjugate in a clinical study, supporting further clinical ...
Guolan Lu, Naoki Nishio, Nynke S. van den Berg, Brock A. Martin, Shayan Fakurnejad, Stan van Keulen, Alexander D. Colevas, Greg M. Thurber, Eben L. Rosenthal   +8 more
doaj   +1 more source

Pneumococcal serotype-specific antibodies persist through early childhood after infant immunization: follow-up from a randomized controlled trial [PDF]

, 2014
BACKGROUND: In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age.
Trück, J, Yu, Ly-Mee, Finn, Adam, Ly-Mee Yu (44961), Pollard, Andrew J, Pollard Andrew J., Trück, Johannes; https://orcid.org/, Faust, Saul N, Johannes Trück, Merryn Voysey, Paul T. Heath (533551), Yu Ly-Mee, Voysey, M, Saul N. Faust (415924), Tatangeli, F, Andrew J Pollard, Voysey Merryn, Heath Paul T., Tatangeli, Florencia, Adam Finn (23223), Florencia Tatangeli (533550), Faust, S.N., Snape, MD, Pollard, AJ, Pollard, Andrew, Heath, PT, Adam Finn, Snape, Matthew, Merryn Voysey (255058), Faust Saul N., Andrew J. Pollard (44971), Snape Matthew D., Heath, Paul T, Voysey, Merryn, Yu, LM, Paul T Heath, Finn Adam, Tatangeli Florencia, Matthew D. Snape (533549), Faust, SN, Matthew D Snape, Finn, A, Snape, Matthew D, Florencia Tatangeli, Saul N Faust, Pollard, Andrew J., Ly-Mee Yu, Johannes Trück (533548), Truck, Johannes, Trück Johannes, Heath, Paul   +50 more
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Emerging Pharmacotherapy for Relapsed or Refractory Hodgkins Lymphoma: Focus on Brentuximab Vedotin

Clinical Medicine Insights: Oncology, 2012
Hodgkins lymphoma (HL) which has relapsed post or is refractory to autologous bone marrow transplant presents an ongoing treatment challenge. Development of monoclonal antibodies (mAb) for the treatment of HL has aimed to replicate the success of mAb ...
Michelle Furtado, Simon Rule
doaj   +1 more source

Development, Validation and Application of a Bridging ELISA for Detection of Antibodies against GQ1001 in Cynomolgus Monkey Serum

Molecules, 2023
Immunogenicity is a major issue associated with the PK, efficacy, and safety evaluation of therapeutic protein products during pre-clinical and clinical studies. A multi-tiered approach consisting of screening, confirmatory, and titration assays has been
Tingting Liu, Yajun Sun, Xiaojie Deng, Lili Shi, Wenyi Chen, Wenjing Fang, Junliang Wu, Xiaotian Fan, Xiaoqiang Chen, Jianhua Sun, Gang Qin, Likun Gong, Qiuping Qin   +12 more
doaj   +1 more source

Vaccination of risk groups in England using the 13 valent pneumococcal conjugate vaccine: economic analysis. [PDF]

, 2012
OBJECTIVE: To estimate the cost effectiveness of vaccinating people with high risk conditions against invasive pneumococcal disease using the 13 valent pneumococcal conjugate vaccine.
Edmunds, W. John, van Hoek, Albert Jan, Trotter, Caroline L, Rozenbaum, Mark H., C. L. Trotter, Miller, Elizabeth, Rozenbaum, Mark H, D. Fleming, Trotter, Caroline L., E. Miller, M. H. Rozenbaum, Edmunds, W John, W. J. Edmunds, Fleming, Douglas, A. J. van Hoek   +14 more
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Additional file 2 of An amino acid transporter subunit as an antibody–drug conjugate target in colorectal cancer

, 2023
Additional file 2: Supplementary Fig. 2. A) Internalization of the anti-CD98hcECTO antibody in SW480 cells, analyzed by immunofluorescence. Scale bar = 25 μm.
Pandiella, Atanasio, Fernández-Barral, Asunción, Atanasio Pandiella (195056), Sayagués, José María, Sofía del Carmen (12277812), Mar Abad (121361), Montero, Juan Carlos, Muñoz Terol, Alberto, Antonio Barbáchano (16809289), Asunción Fernández-Barral (175687), Carmen, Sofía del, Barbáchano, Antonio, Juan Carlos Montero (12277806), Alberto Muñoz (16533), Abad, Mar, José M. Sayagués (16809286)   +15 more
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Novel method for screening functional antibody with comprehensive analysis of its immunoliposome

Scientific Reports, 2021
Development of monoclonal antibody is critical for targeted drug delivery because its characteristics determine improved therapeutic efficacy and reduced side-effect.
Shusei Hamamichi, Takeshi Fukuhara, Izumi O. Umeda, Hirofumi Fujii, Nobutaka Hattori   +4 more
doaj   +1 more source

Toward Homogenous Antibody Drug Conjugates Using Enzyme-Based Conjugation Approaches

Pharmaceuticals, 2021
In the last few decades, antibody-based diagnostic and therapeutic applications have been well established in medicine and have revolutionized cancer managements by improving tumor detection and treatment.
Ahmad Fawzi Hussain, Armin Grimm, Wenjie Sheng, Chaoyu Zhang, Marwah Al-Rawe, Karen Bräutigam, Mobarak Abu Mraheil, Felix Zeppernick, Ivo Meinhold-Heerlein   +8 more
doaj   +1 more source