Results 31 to 40 of about 89,831 (244)

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]

, 2020
Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Arias-Muñoz, Eloisa, Bandau, Susanne, Burgos, Patricia V., Bustamante, Hianara A., Cancino, Jorge, Cerda-Troncoso, Cristóbal, Cereceda, Karina, Cheuquemilla, Yorka, González, Alexis E., Hay, Ronald T., Hernández, Sergio, Kausel, Gudrun, Kerr, Bredford, Mardones, Gonzalo A., Rojas-Fernandez, Alejandro, Soza, Andrea, Valenzuela, Guillermo E.   +16 more
core   +2 more sources

Antibody–Drug Conjugates: The Last Decade

Pharmaceuticals, 2020
An armed antibody (antibody–drug conjugate or ADC) is a vectorized chemotherapy, which results from the grafting of a cytotoxic agent onto a monoclonal antibody via a judiciously constructed spacer arm.
Nicolas Joubert, Alain Beck, Charles Dumontet, Caroline Denevault-Sabourin   +3 more
doaj   +1 more source

Biological properties of adriamycin bound to biodegradable polymeric carriers [PDF]

, 1993
Three different conjugates having adriamycin (ADR) bound to the side chain carboxyl groups of high-molecular weight poly (¿--glutamic acid) (PGA) either directly or by interpolation of GlyGly and GlyGlyGlyLeu spacers, respectively, were compared with ...
Bhakoo, M., Bouma, J.M.W., Duncan, R., Feijen, Jan, Grootoonk, J., Grootoonk, J., Hoes, C.J.T., Hoes, C.J.T., Hume, I.C.   +8 more
core   +3 more sources

Multi-omics elucidation of KDM5C, KDM6A, and KMT2B roles in cancer epigenetic dysregulation and transcriptional reprogramming

Communications Biology
Histone-modifying enzymes (HMEs) are critical regulators of tumorigenesis through epigenetic reprogramming. While mutations in HMEs are recognized drivers of cancer epigenome dysregulation, systematic comparative analyses of their mutational impacts and ...
Tengjiao Li, Lichen Wang, Shoufeng Duan, Xinyu Cui, Chunqing Fu, Jinglei Hu, Lin Li   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Antibody-Drug Conjugates in Solid Tumors

healthbook TIMES. Oncology Hematology, 2022
Solid tumors account for approximately 90% of all types of cancer. For many tumor types, the availability of effective treatment options is limited and new targeted approaches that offer the potential for long-term survival are warranted.
Ilaria Colombo, Alfred Zippelius
doaj   +1 more source

Cutaneous Lymphoma and Antibody-Directed Therapies

Antibodies, 2023
The introduction of monoclonal antibodies such as rituximab to the treatment of cancer has greatly advanced the treatment scenario in onco-hematology. However, the response to these agents may be limited by insufficient efficacy or resistance.
Alvise Sernicola, Christian Ciolfi, Paola Miceli, Mauro Alaibac   +3 more
doaj   +1 more source

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Drug conjugates for targeting regulatory T cells in the tumor microenvironment: guided missiles for cancer treatment

Experimental and Molecular Medicine, 2023
Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in suppressing anticancer immune responses; therefore, various strategies targeting Tregs are becoming important for tumor therapy.
Juwon Yang, Hyunsu Bae
doaj   +1 more source