Results 41 to 50 of about 89,831 (244)

Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles [PDF]

, 2015
The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment. Water soluble gold nanoparticles (ca.
Allen, Arap, Bechet, Bertrand, Boya, Bullous, David A. Russell, Davis, Dougherty, Gary-Bobo, Girgis Obaid, Hamblin, Harris, Hogemann-Savellano, Hone, Isabelle Chambrier, Iversen, Jeyaprakash, Jin, Kim, Konska, Kopeček, Lindig, Marín, Mew, Michael J. Cook, Obaid, Oleinick, Orlova, Poiroux, Qualls, Robertson, Ross, Schafer, Schrama, Slamon, Spring, Springer, Stuchinskaya, Sudimack, Tang, Vacha, Wang, Weissenbock, Wieder, Xu, Yarden, Yu, Yu, Zhang   +49 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Antibody–Drug Conjugates for Cancer Therapy

Biomedicines, 2016
Antibody–drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Adam C. Parslow, Sagun Parakh, Fook-Thean Lee, Hui K. Gan, Andrew M. Scott   +4 more
doaj   +1 more source

A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome [PDF]

, 2007
E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1.
Amerik A. Y., Babbitt S. E., Bertolaet B. L., Bertolaet B. L., Biggins S., Chen L., Cheng I. H., Ciechanover A., Deshaies R. J., Deveraux Q., Elsasser S., Elsasser S., Elsasser S., Finley D., Funakoshi M., Gandre S., Glickman M. H., Guthrie C., Haas A. L., Haracska L., Hicke L., Hofmann K., Johnson E. S., Kang Y., Kleijnen M. F., Kulka R. G., Lambertson D., Lambertson D., Lowe E. D., Madura K., McGrath J. P., Nazli Ghaboosi, Ortolan T. G., Peng J., Pickart C. M., Raasi S., Raasi S., Rao H., Raymond J. Deshaies, Richly H., Ryu K. S., Saeki Y., Saeki Y., Saeki Y., Salvat C., Schauber C., Schuberth C., Shimada K., Swanson R., Swanson R., van Nocker S., van Nocker S., Verma R., Verma R., Verma R., Walters K. J., Walters K. J., Watkins J. F., Wilkinson C.R.M., William Tansey   +59 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Antibody Drug Conjugates as Cancer Therapeutics

Antibodies, 2013
Monoclonal antibody (MAb) based therapies have achieved considerable success in oncology, primarily when used in combination with cytotoxic drugs. Antibody drug conjugates (ADCs) are a class of therapeutics that harness the antigen-selectivity of MAbs to
Pamela A. Trail
doaj   +1 more source

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]

, 2013
p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
A Arlt, A Haririnia, A Hishiya, A Peth, A Sparks, AK Hock, AM Ruschak, AS Fatimababy, B Cross, C Brignone, C Wojcik, CF Cheok, D Finley, D Pei, EG Mimnaugh, G Lozano, GL Bond, H Fu, H Fu, H Higashitsuji, H Hiyama, H Inuzuka, H Inuzuka, H Kawahara, HT Kim, I Dikic, J Boehringer, J Das, J Hamazaki, JD Oliner, JD Shaughnessy Jr., JM Stommel, JM Winget, K Husnjak, K Itahana, L Bedford, LF Stevenson, LJ Crawford, LK Linares, LR Dick, LT Vassilev, M Elangovan, M Elangovan, M Isasa, M K Saville, M Kaur, M Wade, M Wade, MD Kaeser, MF Kleijnen, MH Glickman, MJ Lee, MK Saville, MP Bousquet-Dubouch, N Allende-Vega, N Allende-Vega, N Allende-Vega, N Gallastegui, NP Dantuma, NP Dantuma, P Robertson, P Sdek, P Young, PG Santamaria, Q Xu, Q Zhu, R Kulikov, R Verma, S Carter, S Dayal, S Dayal, S Elsasser, S Glockzin, S Menendez, S Nickell, S Raasi, SJ Wei, T Kaneko, T Mayor, T Szlanka, TA Gomez, V Su, VD Nair, XM Sun, Y Jin, Y Kravtsova-Ivantsiv, Y Midorikawa, Y Saeki, Y Wan, YA Lam, YH Shen, YV Wang, Z Lipinszki, Z Lipinszki   +93 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Generation of binder-format-payload conjugate-matrices by antibody chain-exchange

Nature Communications
The generation of antibody-drug conjugates with optimal functionality depends on many parameters. These include binder epitope, antibody format, linker composition, conjugation site(s), drug-to-antibody ratio, and conjugation method.
Vedran Vasic, Steffen Dickopf, Nadine Spranger, Rose-Sophie Rosenberger, Michaela Fischer, Klaus Mayer, Vincent Larraillet, Jack A. Bates, Verena Maier, Tatjana Sela, Bianca Nussbaum, Harald Duerr, Stefan Dengl, Ulrich Brinkmann   +13 more
doaj   +1 more source

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

mAbs, 2021
Early success with brentuximab vedotin in treating classical Hodgkin lymphoma spurred an influx of at least 20 monomethyl auristatin E (MMAE) antibody-drug conjugates (ADCs) into clinical trials.
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Danielle Mandikian, Yonglian Sun, Zhonghua Lin, Kellen Schneider, Pamela Zhang, Rajesh Vij, Danielle Sharpnack, Pamela Chan, Cecile de la Cruz, Jack Sadowsky, Dhaya Seshasayee, James T. Koerber, Thomas H. Pillow, Gail D. Phillips, Rebecca K Rowntree, C. Andrew Boswell, Katherine R. Kozak, Andrew G. Polson, Paul Polakis, Shang-Fan Yu, Peter S. Dragovich, Nicholas J. Agard   +26 more
doaj   +1 more source