Results 181 to 190 of about 140,297 (347)

Association of Elevated Serum S100A8/A9 Levels and Cognitive Impairment in Patients With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Cognitive impairment (CI) is common in patients with systemic lupus erythematosus (SLE). Despite its prevalence, the immune mechanisms are not well understood. We previously reported elevated serum levels of S100A8/A9 and matrix metalloproteinase 9 (MMP‐9) in patients with SLE and CI.
Carolina Muñoz‐Grajales, Michelle L. Barraclough, Juan P. Diaz‐Martinez, Jiandong Su, Kathleen Bingham, Mahta Kakvan, Roberta Pozzi Kretzmann, Maria Carmela Tartaglia, Lesley Ruttan, May Y. Choi, Simone Appenzeller, Sherief Marzouk, Dennisse Bonilla, Patricia Katz, Dorcas Beaton, Robin Green, Dafna D. Gladman, Joan Wither, Zahi Touma   +18 more
wiley   +1 more source

Analytical methods for physicochemical characterization of antibody drug conjugates

, 2011
Aditya A. Wakankar, Yan Chen, Yatin R. Gokarn, Fredric S. Jacobson   +3 more
openalex   +1 more source

Effectiveness and safety of baricitinib for juvenile idiopathic arthritis associated uveitis or chronic anterior antinuclear antibody positive uveitis

Arthritis Care &Research, Accepted Article.
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Antibody–drug conjugates as novel anti-cancer chemotherapeutics [PDF]

, 2015
Christina Peters, Stuart Brown
openalex   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Nano - drug delivery of apoptosis activator 2 to AGS cells by liposomes conjugated with anti-TROP2 antibody

, 2012
TaghiNaserpour Farivar, Reza Najafipour, Pouran Johari   +2 more
openalex   +2 more sources

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate? [PDF]

Onco Targets Ther
Zhao Q, Luo X, Xing H, Jiang C, Ma J, Tang L.   +5 more
europepmc   +1 more source

Targeted Delivery of LXR Agonist Using a Site-Specific Antibody–Drug Conjugate [PDF]

, 2015
Reyna K. V. Lim, Shan Yu, Bo Cheng, Sijia Li, Nam‐Jung Kim, Yu Cao, Victor Chi, Ji Young Kim, Arnab K. Chatterjee, Peter G. Schultz, Matthew S. Tremblay, Stephanie A. Kazane   +11 more
openalex   +1 more source

ANTIBODY DRUG CONJUGATES (ADCS)

HemaSphere, 2023
openaire   +2 more sources