Results 211 to 220 of about 145,743 (338)

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Data from ABBV-011, A Novel, Calicheamicin-Based Antibody–Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors

, 2023
Wolf R. Wiedemeyer, Julia Gavrilyuk, Alexander Schammel, Xi Zhao, Hetal Sarvaiya, Marybeth A. Pysz, Christine Gu, Monica You, Kumiko Isse, Theodore Sullivan, Dorothy French, Christina Lee, Angeline Tilly Dang, Zhaomei Zhang, Monette Aujay, Alexander J. Bankovich, Philip Vitorino   +16 more
openalex   +1 more source

Targeting uPARAP with an Antibody-Drug Conjugate Exhibits Efficacy against Mesothelioma and Synergizes with Cisplatin. [PDF]

Cancer Res Commun
Çakılkaya P, Egeland Larsen IM, Jiang Q, Sandal Nørregaard K, Gårdsvoll H, Zhang J, Jürgensen HJ, Hansen Blomquist M, Martinez Perlado A, Krigslund O, Santoni-Rugiu E, Engelholm LH, Hassan R, Behrendt N.   +13 more
europepmc   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Updates on Antibody Drug Conjugates and Bispecific T-Cell Engagers in SCLC [PDF]

Kinsley Wang, Kyle Taing, Robert Hsu
openalex   +1 more source

Table S2 from PCA062, a P-cadherin Targeting Antibody–Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin–expressing Malignancies

, 2023
Quan Z. Sheng, Joseph A. D’Alessio, Daniel L. Menezes, Christopher Karim, Yan Tang, Angela Tam, Suzanna Clark, Ying Chi, Anu Connor, Keith G. Mansfield, Jean‐Michel Rondeau, Majid Ghoddusi, Felipe C. Geyer, Jane Gu, Margaret E. McLaughlin, Rick Newcombe, GiNell Elliot, William R. Tschantz, Sylvie Lehmann, Christie Fanton, Kathy D. Miller, Thomas Huber, Katherine G. Rendahl, Ursula Jeffry, Nancy Pryer, Emma Lees, Paul Kwon, Judith A. Abraham, Jason S. Damiano, Tinya J. Abrams   +29 more
openalex   +1 more source

Comparative In Vitro Evaluation of Anti-HIV Immunotoxin, Antibody-Drug Conjugate, and Radioimmunoconjugate Targeted by the Same Antibody. [PDF]

Antibodies (Basel)
Kuhlmann AS, Peters T, Hamlin DK, Li Y, Wang X, Stackhouse M, Cole FM, Martinez-Reyes J, Sandmaier BM, Kiem HP, Wilbur DS, Harrington RD, Pincus SH.   +12 more
europepmc   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Staging metastatic urothelial cancer with Nectin-4 imaging by 68Ga-N188 positron emission tomography for personalized antibody drug conjugate therapy

C. Thomas, M. Pretze, A. Hartig, J.D.M. Ferraira, K. Böhm, S. Hoberück, RA Bundschuh   +6 more
openalex   +1 more source

Mat & Met S5 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities

, 2023
Céline Nicolazzi, Anne Caron, Alexia Tellier, Marc Trombe, Jan Pinkas, Gillian Payne, Chantal Carrez, S. Guérif, Marie Maguin, Raffaele Baffa, Matteo Fassan, Julien Adam, Lydie Mangatal-Wade, Véronique Blanc   +13 more
openalex   +1 more source