Results 41 to 50 of about 2,263,596 (244)

Clinical Pharmacology of Antibody-Drug Conjugates

Antibodies, 2021
Antibody-drug conjugates (ADCs) are biopharmaceutical products where a monoclonal antibody is linked to a biologically active drug (a small molecule) forming a conjugate.
Iftekhar Mahmood
doaj   +1 more source

Antibody drug conjugates in cancer therapy

, 2023
This thesis delves into the exploration of Antibody Drug Conjugates (ADCs) in cancer therapy, tracing their evolution from conception to the present day. Throughout the years, researchers and drug developers have made significant strides in enhancing the
Nagar, Noah Benjamin
core  

Antibody Drug Conjugates: A Leap Ahead in Cancer Treatment [PDF]

, 2014
Monoclonal antibody (MAb) based targeted therapies have achieved appreciable success in various branches of drug therapeutics, predominantly when used along with cytotoxic drugs. These immunological therapies based on antibody-drug conjugates (ADCs) have
Kaur, Ishpreet, Singh, Harsharan Pal, Gullaiya, Sumeet   +2 more
core   +1 more source

Antibody-drug conjugates: beyond current approvals and potential future strategies

, 2022
The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in recent years have fuelled the ongoing development of this class of drugs.
Siddharth Menon (9474608), Sagun Parakh (9493061), Andrew Scott (9483443), Hui Gan (9477872)   +3 more
core   +1 more source

Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates [PDF]

, 2023
Antibody-drug conjugates consist of potent small molecule payloads linked to a targeting antibody. Payloads must possess a viable functional group by which a linker for conjugation can be attached.
Axel, Hernandez, Jr., Martin, Hayes, Michael, McPherson, Agnieszka, Bischoff, Thomas, Vargo, Margaret, Fettis, Lu, Wang, Yu, Tian, Adrian, Hobson, Ying, Jia, Jason, Oh, Christopher, Marvin, Theresa, Dunstan   +12 more
core   +2 more sources

Antibody-drug conjugates

Practical oncology, 2023
This article is a literature review of the available data on the history of origin, mechanism of action, and the main currently available conjugate-linked monoclonal antibodies. The use of conjugate-linked monoclonal antibodies in the therapy of both solid and hematological malignancies is a promising direction of anti-tumor therapy.
E.O. Stepanova, F.V. Moiseenko, V.M. Moiseyenko   +2 more
openaire   +2 more sources

Multi-omics elucidation of KDM5C, KDM6A, and KMT2B roles in cancer epigenetic dysregulation and transcriptional reprogramming

Communications Biology
Histone-modifying enzymes (HMEs) are critical regulators of tumorigenesis through epigenetic reprogramming. While mutations in HMEs are recognized drivers of cancer epigenome dysregulation, systematic comparative analyses of their mutational impacts and ...
Tengjiao Li, Lichen Wang, Shoufeng Duan, Xinyu Cui, Chunqing Fu, Jinglei Hu, Lin Li   +6 more
doaj   +1 more source

Antibody Conjugates via Disulfide Bridging: Towards therapeutic and diagnostic applications [PDF]

, 2015
Antibodies play a prominent role in chemical and biological research and the largest application of chemical bioconjugation reagents is in the production of antibody conjugates.
Hull, EA
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

High-sensitive glycomics using seGRAP-mass spectrometry uncovers a conserved N-glycome in single human oocytes

Nature Communications
High-sensitivity glycomic analysis is essential for advancing both basic and translational biomedical research, yet remains methodologically challenging for limited-quantity samples, primarily due to complex workflows and reliance on specialized ...
Nafisa Tursumamat, Qiannan Liu, Jihong Lu, Shuhong Guo, Shuangshuang Du, Shengyang Liu, Shuye Wu, Heming Li, Peng Wu, Bin Li, Juan Wei   +10 more
doaj   +1 more source