Results 51 to 60 of about 2,263,596 (244)

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Maruani, A, Caddick, S, Smith, ME, Chester, KA, Chudasama, V, Miranda, E   +5 more
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Chemoenzymatic glycan labelling as a platform for site-specific IgM-antibody drug conjugates

, 2019
Immunoglobulin M (IgM) type antibodies play a significant role in complement activation, cellular debris clearance and cell quality control, and have the potential to be used as a therapeutic or targeting/delivery antibody.
Packer, Nicolle H, Sayyadi, Nima, Moh, Edward SX   +2 more
core   +1 more source

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

, 2023
International audienceEither as full IgGs or as fragments (Fabs, Fc, etc.), antibodies have received tremendous attention in the development of new therapeutics such as antibody-drug conjugates (ADCs).
Baker, James R., Chudasama, Vijay, Thoreau, Fabien, Rochet, Léa N. C.   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Self-polymerized polyphenol-based platform for the management of dry eye pathogenesis

Nature Communications
The management of ocular surface inflammation, particularly in conditions like dry eye disease (DED), remains challenging due to multiple pathogenic causes and ocular barriers.
Zixin Wang, Zeen Lv, Yuxuan Ge, Ruiyang Xue, Fang Wu, Haijie Han, Yin Wang   +6 more
doaj   +1 more source

Antibody–Drug Conjugates: The Last Decade

Pharmaceuticals, 2020
An armed antibody (antibody–drug conjugate or ADC) is a vectorized chemotherapy, which results from the grafting of a cytotoxic agent onto a monoclonal antibody via a judiciously constructed spacer arm.
Nicolas Joubert, Alain Beck, Charles Dumontet, Caroline Denevault-Sabourin   +3 more
doaj   +1 more source

Drug conjugates for targeting regulatory T cells in the tumor microenvironment: guided missiles for cancer treatment

Experimental and Molecular Medicine, 2023
Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in suppressing anticancer immune responses; therefore, various strategies targeting Tregs are becoming important for tumor therapy.
Juwon Yang, Hyunsu Bae
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Antibody-Drug Conjugates in Solid Tumors

healthbook TIMES. Oncology Hematology, 2022
Solid tumors account for approximately 90% of all types of cancer. For many tumor types, the availability of effective treatment options is limited and new targeted approaches that offer the potential for long-term survival are warranted.
Ilaria Colombo, Alfred Zippelius
doaj   +1 more source