Results 191 to 200 of about 348,994 (265)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

In vivo production of an anti-HIV antibody in mice by non-viral gene knockin in primate hematopoietic stem and progenitor cells. [PDF]

Mol Ther
Castelli JMP, Poljakov K, Jwa Y, Cunningham R, Cassidy ME, Gray MD, Sanchez Gaytan JN, Enstrom MR, Gastelum G, Wang Z, Linton JD, Rongvaux A, Taylor JJ, Adair JE.   +13 more
europepmc   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Re-shaping the immune response to influenza vaccination in a host with immune memory from influenza infection. [PDF]

NPJ Vaccines
White CL, Mengu L, Sidhu IS, Gandhapudi SK, Richards KA, Sant AJ.   +5 more
europepmc   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Humoral and cellular immune response after COVID-19 vaccination in patients with sickle cell disease on hydroxyurea. [PDF]

Blood Adv
Haggenburg S, Pothast CR, Hofsink Q, Haverkate NJE, Bhoekhan MS, Claireaux M, van Binnendijk RS, Hartog GD, Lissenberg-Witte BI, de Vries RD, van Tuijn C, Biemond BJ, Nur E, Geurts van Kessel CH, Mutsaers PGNJ, Broers AEC, Goorhuis A, Nijhof IS, van Gils MJ, Heemskerk MHM, Hazenberg MD, Rutten CE, van Meerloo JJH, Smit GP, Wouters D, van Leeuwen EMM, Bontkes HJ, Kootstra N, Kant IMJ, Graas T, Toussaint B, de Jong S, Darwesh S, Mahes SS, Kamminga D, Koelewijn M, Faber G, Beaumont G, Engel MD, Pierie RCN, Janssen SR, Faber G, Groen K, Burger JA, Bouhuijs JH, Baars PA, van Dijkman E, Heijmans J, Witte YY, Nahui Palomino RA, Omar SZ, Zweegman S, Kater AP, van den Vegt C, Arends-Halbesma I, de Pater E, Dijkstra MJ, van Beek J, Rots NY, Rijnstra ES, de Rooij DM, Sanders RW, Poniman M, Olijhoek W, van Rijswijk J, Beaumont T, Çetinel L, Schellekens L, den Hartogh YM, Cloos J, Weijers SS, Tonouh-Aajoud S, Avci S, Roelandse-Koop E, Dik WA, Vogels-Nooijen S.   +75 more
europepmc   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Significance of RGS13 expression in lupus B cells. [PDF]

PLoS One
Nakajima T, Kitagori K, Funakoshi S, Shirakashi M, Hiwa R, Tsuji H, Akizuki S, Nakashima R, Morinobu A, Yoshifuji H.   +9 more
europepmc   +1 more source

Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling ...
Jae‐Won Hyun, Shaun G. Hong, Na Young Park, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source