Results 71 to 80 of about 348,994 (265)

Vaccine-Induced Measles Virus-Specific T Cells Do Not Prevent Infection or Disease but Facilitate Subsequent Clearance of Viral RNA

mBio, 2014
Infection with wild-type measles virus (MeV) induces lifelong protection from reinfection, and parenteral delivery of the live attenuated measles vaccine (LAV) also provides protection from measles.
Wen-Hsuan W. Lin, Chien-Hsiung Pan, Robert J. Adams, Beth L. Laube, Diane E. Griffin   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Production of IgY Specific Antibody Against Entero Pathogenic Escherichia coli (EPEC) in Egg Yolk

Jurnal Kedokteran Hewan, 2008
Antibody to Enteropathogenic Eschericia coli (EPEC) K1.1. can be produced in egg yolk by the application of inactivated bacterial cells intravenously in layer chicken. The presence of specific antibody in sera and egg can be detected with immunodiffusion
I Wayan Teguh Wibawan, Fachriyan H. Pasaribu, Rudi Rawendra   +2 more
doaj   +1 more source

IgG4 Autoantibodies in Organ-Specific Autoimmunopathies: Reviewing Class Switching, Antibody-Producing Cells, and Specific Immunotherapies. [PDF]

Front Immunol, 2022
Koneczny I, Tzartos J, Mané-Damas M, Yilmaz V, Huijbers MG, Lazaridis K, Höftberger R, Tüzün E, Martinez-Martinez P, Tzartos S, Leypoldt F.   +10 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Polyfunctional T peripheral helper cells are associated with the magnitude and durability of antibody responses after COVID‐19

Clinical & Translational Immunology
Objective Examine the role of T cells in shaping and sustaining humoral immunity to SARS‐CoV‐2 and identify immune factors associated with durable antibody responses.
Katie Tungatt, Gabriela Martins Costa Gomes, Nicole L Fewings, Aija Stubis, Chloe M Doyle, Vera Merheb, Anupriya Aggarwal, Karen Byth, Harry Robertson, Suat Dervish, Susan Maddocks, Janette Taylor, Rowena A Bull, Marianne Martinello, the COSIN Protocol Steering Committee, Fabienne Brilot, Stuart G Turville, Anthony L Cunningham, Kerrie J Sandgren   +18 more
doaj   +1 more source

Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

Arthritis Research & Therapy, 2017
Background Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs.
Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio   +13 more
doaj   +1 more source

Mixed xenogeneic porcine chimerism tolerizes human anti-pig natural antibody-producing cells in a humanized mouse model. [PDF]

Xenotransplantation, 2021
Waffarn EE, Khosravi-Maharlooei M, Khosravi-Maharlooei M, Vecchione A, Shao S, Vishwasrao P, HÖlzl MA, Frangaj K, Sykes M, Li HW.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effects of Allogenic and Effector Cells on the Development of Antibody-Producing Cells, In Vitro

Experimental Biology and Medicine, 1975
Effects of allogenic and effector spleen cells on the development of anti-SRBC plaque-forming cells from target spleen cells in vitro were studied. Addition of allogeneic cells resulted in various degrees of suppression of target cell PFC production. This allogeneic suppression could be abolished by pretreating the cells with either uv or X irradiation.
Pazdernik, T L, Uyeki, E M
openaire   +2 more sources