Results 131 to 140 of about 3,380,570 (289)

The Heat Produced by Reactions of Antigens with Antibodies [PDF]

, 1925
Stanhope Bayne‐Jones
openalex   +1 more source

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

Nature Communications
We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune responses where antigen-specific clones with the same heavy (VH) and light chain germline ...
Yi-Chun Hsiao, Heidi Ackerly Wallweber, Robert G. Alberstein, Zhonghua Lin, Changchun Du, Ainhoa Etxeberria, Theint Aung, Yonglei Shang, Dhaya Seshasayee, Franziska Seeger, Andrew M. Watkins, David V. Hansen, Christopher J. Bohlen, Peter L. Hsu, Isidro Hötzel   +14 more
doaj   +1 more source

Relation-Aware Equivariant Graph Networks for Epitope-Unknown Antibody Design and Specificity Optimization [PDF]

arXiv
Antibodies are Y-shaped proteins that protect the host by binding to specific antigens, and their binding is mainly determined by the Complementary Determining Regions (CDRs) in the antibody. Despite the great progress made in CDR design, existing computational methods still encounter several challenges: 1) poor capability of modeling complex CDRs with
arxiv  

Neutralizing Antibodies Against Certain Viruses in the Sera of Residents of India

, 1954
K. C. Smithburn, J. A. Kerr, P. B. Gatne
openalex   +1 more source

GROUP A HEMOLYTIC STREPTOCOCCUS ANTIBODIES. I. GRIFFITH TYPE AGGLUTININ AND ANTISTREPTOLYSIN TITERS IN NORMAL MEN AND IN ACUTE INFECTIONS [PDF]

, 1943
Lowell A. Rantz, William Kirby, Alvin H. Jacobs   +2 more
openalex   +1 more source

Deep-learning image analysis for high-throughput screening of opsono-phagocytosis-promoting monoclonal antibodies against Neisseria gonorrhoeae

Scientific Reports
Antimicrobial resistance (AMR) is nowadays a global health concern as bacterial pathogens are increasingly developing resistance to antibiotics. Monoclonal antibodies (mAbs) represent a powerful tool for addressing AMR thanks to their high specificity ...
Fabiola Vacca, Dario Cardamone, Emanuele Andreano, Duccio Medini, Rino Rappuoli, Claudia Sala   +5 more
doaj   +1 more source

ANTITULARENSE SERUM: CORRELATION BETWEEN PROTECTIVE CAPACITY FOR WHITE RATS AND PRECIPITABLE ANTIBODY CONTENT [PDF]

, 1947
Lee Foshay, I. Ruchman, P. S. Nicholes
openalex   +1 more source

Large scale paired antibody language models [PDF]

arXiv
Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in ...
arxiv  

On the Inheritance of Acquired Antibodies [PDF]

, 1923
James Learmonth
openalex   +1 more source

ANTIPASTI: interpretable prediction of antibody binding affinity exploiting Normal Modes and Deep Learning [PDF]

arXiv
The high binding affinity of antibodies towards their cognate targets is key to eliciting effective immune responses, as well as to the use of antibodies as research and therapeutic tools. Here, we propose ANTIPASTI, a Convolutional Neural Network model that achieves state-of-the-art performance in the prediction of antibody binding affinity using as ...
arxiv