Results 171 to 180 of about 2,490,885 (297)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

An Overview of Liquid Chromatography-Mass Spectrometry (LC-MS) Methods for the Quantification of Antibody-Drug Conjugates. [PDF]

Biomed Chromatogr
Buitelaar PLM, Rosing H, Beijnen JH, Steeghs N, Huitema ADR.   +4 more
europepmc   +1 more source

A standardised pre-clinical in-vitro blood-brain barrier mouse assay validates endocytosis dependent antibody transcytosis using transferrin receptor-mediated pathways

, 2022
Jamie I. Morrison, Alex Petrovic, Nicole G. Metzendorf, Fadi Rofo, Canan Uğur Yılmaz, Sofia Stenler, Hanna Laudon, Greta Hultqvist   +7 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A Novel In-Cell ELISA With Superior Sensitivity and Specificity for the Detection of African Swine Fever Virus-Specific IgM and IgG Antibodies. [PDF]

Transbound Emerg Dis
Wu P, McDaniel AJ, Rodríguez YY, O'Donnell V, Jia W.   +4 more
europepmc   +1 more source

Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion [PDF]

, 2019
M. Kathryn Brewer, Annette Uittenbogaard, Grant L. Austin, John J. McCarthy, Dyann M. Segvich, Anna Depaoli-Roach, Peter J. Roach, Bradley L. Hodges, Jill Zeller, James R. Pauly, Tracy R. McKnight, Dustin Armstrong, Matthew S. Gentry   +12 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Epitope-level analysis of cross-reactive human HLA antibodies against genetically modified swine leukocyte antigens in xenotransplantation. [PDF]

Front Immunol
Cho SI, Yan JJ, Kim BS, Ko N, Shim J, Kim H, Oh EJ.   +6 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

A Rapid Method Based on Colloidal Selenium Nanoparticle to Detect NT-proBNP Antigen in Serum for Monitoring Acute Heart Failure. [PDF]

Int J Nanomedicine
Tang C, Xiang H, Zhu J, Chen T, Shao J, Gu L, Shen Y, Zhu Y.   +7 more
europepmc   +1 more source