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Designing stable humanized antibodies
Nature Biomedical Engineering, 2023Alissa M. Hummer, Charlotte M. Deane
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Researchers create designer antibody
BMJ, 1998Immunologists have designed an antibody that can specifically suppress just one section of the immune system, rather than having to knock out the whole system. This antibody could revolutionise the lives of people who undergo organ transplantation because the T lymphocytes that cause organ rejection could be selectively “turned off” by it, leaving the ...
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Antibody Affinity Maturation by Computational Design
2018The immune systems protect our bodies from foreign molecules or antigens, where antibodies play important roles. Antibodies evolve over time upon antigen encounter by somatically mutating their genome sequences. The end result is a series of antibodies that display higher affinities and specificities to specific antigens.
Daisuke, Kuroda, Kouhei, Tsumoto
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Chapter 15 Designer antibodies
1996Publisher Summary This chapter discusses the antibody structure and biosynthesis, monoclonal antibodies in therapeutics, chimeric and humanized antibodies, expression of antibody fragments in Escherichia Coli, and designer antibody-targeted effector functions.
Andy Minn, Jose Quintans
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Antibody Modeling: Implications for Engineering and Design
Methods, 2000Our understanding of the rules relating sequence to structure in antibodies has led to the development of accurate knowledge-based procedures for antibody modeling. Information gained from the analysis of antibody structures has been successfully exploited to engineer antibody-like molecules endowed with prescribed properties, such as increased ...
Morea V, Lesk, AM, Tramontano, A
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Computer-Aided Antibody Design: An Overview
2017The use of monoclonal antibody as the next generation protein therapeutics with remarkable success has surged the development of antibody engineering to design molecules for optimizing affinity, better efficacy, greater safety and therapeutic function. Therefore, computational methods have become increasingly important to generate hypotheses, interpret
Yee Siew, Choong +4 more
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CD ComputaBio is a leading global company providing compelling and novel solutions in computer-aided drug design. We prioritize the integration of our advanced computational capabilities with our extensive expertise in antibody drug design to offer a range of services.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Catalytic antibodies: designed and accidental
Biochemical Society Transactions, 1993Colin J. Suckling +10 more
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