Results 191 to 200 of about 49,428 (256)

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Targeting IL-7Rα with PNU-159682 antibody-drug conjugates in acute lymphoblastic leukemia: translational implications. [PDF]

MAbs
Yang S, Anzai T, Tsumura R, Fuchigami H, Hamada M, Yuda J, Ikuta K, Yasunaga M.   +7 more
europepmc   +1 more source

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, EarlyView.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

Extracellular payload release from non-internalizing antibody-drug conjugates: mechanisms and linker technologies. [PDF]

Drug Deliv
Feng C, Lou R, Chen S, Lin F, Ge J, Zhang Y, Lin C, Huang C.   +7 more
europepmc   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Strategic and Chemical Advances in Antibody-Drug Conjugates. [PDF]

Pharmaceutics
Alradwan IA, Alnefaie MK, Al Fayez N, Aodah AH, Majrashi MA, Alturki M, Fallatah MM, Almughem FA, Tawfik EA, Alshehri AA.   +9 more
europepmc   +1 more source

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

Advanced Materials, EarlyView.
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz, Matthieu Gelin, Lucas Pradeau‐Phélut, Arrate Muñoz‐Barrutia, Sandrine Etienne‐Manneville, Daniel Garcia‐Gonzalez   +5 more
wiley   +1 more source

Antibody-drug conjugates in cancer treatment: from molecular design to clinical implementation. [PDF]

Lancet Reg Health Eur
Mansinho A, Albuquerque J, Barigazzi C, Calvo E.   +3 more
europepmc   +1 more source

Optimizing Body Size-Based Dosing Approaches for Antibody-Drug Conjugates. [PDF]

Clin Pharmacol Ther
SyBing AB, Wang DD.
europepmc   +1 more source

Antibody-Drug Conjugates Targeting Resistance-Associated Signaling Pathways: Recent Advances and Future Perspectives. [PDF]

Int J Mol Sci
Xie D, Yang C, Gao S, Li J, Yang J, Li X, Jiang R, Cao F, Zhang S, Wang L, Sun M.   +10 more
europepmc   +1 more source