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Antibody–Drug Conjugate Payloads
2013Toxin payloads, or drugs, are the crucial components of therapeutic antibody-drug conjugates (ADCs). This review will give an introduction on the requirements that make a toxic compound suitable to be used in an antitumoral ADC and will summarize the structural and mechanistic features of four drug families that yielded promising results in preclinical
Jan, Anderl +3 more
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Antibody-Drug Conjugate Targets
Current Cancer Drug Targets, 2009The requirements for a cell surface molecule to be suitable as an antibody-drug conjugate target are stringent. The notion that antibodies-directed toward targets on the surface of malignant cells could be used for drug delivery is not new. The history of antibody-drug conjugates has been marked by hurdles identified and overcome. Early conjugates used
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Payloads of Antibody: Drug Conjugates
2015The payload of antibody–drug conjugates (ADCs) is the warhead of ADCs that kills the tumor cells. Three classes of highly potent toxins including maytansinoids, auristatins, and calicheamicins are currently being employed or pursued in the clinic as the payloads of ADCs.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
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Current approaches for the purification of antibody–drug conjugates
Journal of Separation Science, 2022Yutaka Matsuda
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Diazaborines Are a Versatile Platform to Develop ROS‐Responsive Antibody Drug Conjugates**
Angewandte Chemie - International Edition, 2021Luis Filipe Veiros +2 more
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Antibody–drug conjugates: Recent advances in payloads
Acta Pharmaceutica Sinica B, 2023Yuxi Wang, , Hanxuan Li
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Recent advances of antibody drug conjugates for clinical applications
Acta Pharmaceutica Sinica B, 2020Guangya Xiang +2 more
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