Results 181 to 190 of about 4,368,554 (323)

Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods. [PDF]

Int J Mol Sci, 2021
Chae H, Cho S, Jeong M, Kwon K, Choi D, Lee J, Nam W, Hong J, Lee J, Yoon S, Hong H.   +10 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action. [PDF]

Toxins (Basel)
Kalmantaeva OV, Marin MA, Ershova AA, Ryabko AK, Romanenko YO, Kombarova TI, Dyatlov IA, Firstova VV.   +7 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

AntiBMPNN: Structure-Guided Graph Neural Networks for Precision Antibody Engineering. [PDF]

Adv Sci (Weinh)
Sun ZY, Yuan J, Jaiswal D, Ge J, Liang T, Wei J, Cao J, Li Y, Chu X, Chen Y, Xue Y, Li W, Hou T, Feng Z.   +13 more
europepmc   +1 more source

Advances in antibody engineering for rheumatic diseases

Nature Reviews Rheumatology, 2019
A. Schmid, D. Neri
semanticscholar   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Sequence-only prediction of binding affinity changes: a robust and interpretable model for antibody engineering. [PDF]

Bioinformatics
Liu C, Li M, Tan Y, Gou W, Fan G, Zhou B.   +5 more
europepmc   +1 more source

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

Nature Biotechnology, 2021
Susanna K. Elledge, Xin X. Zhou, James R. Byrnes, Alexander J. Martinko, Irene Lui, Katarina Pance, Shion A. Lim, J. Glasgow, A. Glasgow, K. Turcios, N. Iyer, L. Torres, M. Peluso, T. Henrich, Taia T. Wang, C. Tato, K. Leung, B. Greenhouse, J. Wells   +18 more
semanticscholar   +1 more source