Results 171 to 180 of about 5,391,353 (307)

Scaling antibody language models improves structure aware representation for antibody engineering. [PDF]

Commun Biol
Bai S, Liu Z, Feng B, Zhang J, Li Y.
europepmc   +1 more source

Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods. [PDF]

Int J Mol Sci, 2021
Chae H, Cho S, Jeong M, Kwon K, Choi D, Lee J, Nam W, Hong J, Lee J, Yoon S, Hong H.   +10 more
europepmc   +1 more source

Aglycosylated Immunoglobulin G1 Fc Stabilized Through Disulfide Bond Addition Exhibits Compositional Homogeneity and Retains Fc γ Receptor IIIa/CD16a Binding

Background: The interaction between human immunoglobulin G (IgG)1 Fc and the Fc gamma receptor (FcγR) IIIa/CD16a elicits protective immune responses.
Adam W. Barb, Anjali Shenoy, Daniel J. Falconer   +2 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Anti-malaria antibody engineering broadens recognition motifs and reveals new homotypic interactions that enhance protective breadth. [PDF]

Nat Commun
Chun J, Tripathi P, Flores-Garcia Y, Madan B, Lee GA, Fahad AS, Lei H, Teng IT, Hurlburt NK, Flynn BJ, Pancera M, Miura K, Zhou T, Idris AH, Zavala F, Seder RA, Kwong PD, DeKosky BJ.   +17 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

AntiBMPNN: Structure-Guided Graph Neural Networks for Precision Antibody Engineering. [PDF]

Adv Sci (Weinh)
Sun ZY, Yuan J, Jaiswal D, Ge J, Liang T, Wei J, Cao J, Li Y, Chu X, Chen Y, Xue Y, Li W, Hou T, Feng Z.   +13 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Chimeric Antibody Engineering Against <i>Bacillus anthracis</i> Lethal Toxin: Neutralization Efficacy and Mechanism of Action. [PDF]

Toxins (Basel)
Kalmantaeva OV, Marin MA, Ershova AA, Ryabko AK, Romanenko YO, Kombarova TI, Dyatlov IA, Firstova VV.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source