Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizers. [PDF]
Antib Ther, 2021 As the COVID-19 pandemic continues to spread, hundreds of new initiatives including studies on existing medicines are running to fight the disease. To deliver a potentially immediate and lasting treatment to current and emerging SARS-CoV-2 variants, new ...
Riahi S +10 more
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Targeting acute myeloid leukemia through antibody engineering: innovations in immunotherapy and combination regimens. [PDF]
Clin Exp MedAcute myeloid leukemia (AML), a heterogeneous and aggressive hematologic malignancy, remains challenging to treat due to high relapse rates, chemotherapy resistance, and the immunosuppressive tumor microenvironment (TME). While traditional therapies like
Soleimani Samarkhazan H +7 more
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Antibody numbering schemes: advances, comparisons and tools for antibody engineering. [PDF]
Protein Eng Des SelThe evolution of antibody engineering has significantly enhanced the development of antibody-based therapeutics, enabling the creation of novel antibody formats tailored for specific applications.
Zhu Z +6 more
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mmCSM-AB: guiding rational antibody engineering through multiple point mutations. [PDF]
Nucleic Acids Res, 2020 While antibodies are becoming an increasingly important therapeutic class, especially in personalized medicine, their development and optimization has been largely through experimental exploration.
Myung Y, Pires DEV, Ascher DB.
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Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery. [PDF]
Biosci Rep, 2019 The reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the sum of its parts.
Phua SX, Chan KF, Su CT, Poh JJ, Gan SK.
europepmc +2 more sources
IgG Fc engineering to modulate antibody effector functions
Protein & Cell, 2017 Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions.
Xinhua Wang +2 more
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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody. [PDF]
PLoS One, 2018 Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these disorders can be effectively treated with an antibody that inhibits complement C5, the high plasma ...
Sampei Z +15 more
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High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis. [PDF]
Nucleic Acids Res, 2018 Antibody engineering is performed to improve therapeutic properties by directed evolution, usually by high-throughput screening of phage or yeast display libraries. Engineering antibodies in mammalian cells offers advantages associated with expression in
Mason DM +6 more
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Beyond antibody engineering: directed evolution of alternative binding scaffolds and enzymes using yeast surface display. [PDF]
Microb Cell Fact, 2018 Pioneered exactly 20 years ago, yeast surface display (YSD) continues to take a major role in protein engineering among the high-throughput display methodologies that have been developed to date. The classical yeast display technology relies on tethering
Könning D, Kolmar H.
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Microbiology Spectrum, 2014 ABSTRACTAdvanced molecular biology techniques developed during the past few decades have allowed the industry to exploit and commercialize the natural defense mechanisms that antibodies provide. This review discusses the latest advances in antibody-engineering technologies to enhance clinical efficacy and outcomes.
Kin-Ming, Lo +2 more
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