Results 221 to 230 of about 411,227 (332)

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Highlights of Antibody Engineering and Therapeutics 2019 in San Diego, USA: Bispecific Antibody Design and Clinical Applications. [PDF]

Antib Ther, 2020
Zhu Y, Shen R, Hao R, Wang S, Ho M.
europepmc   +1 more source

3P099 Protein engineering approach for point bioconjugation: How a specific lysine residue can be designed on an antibody for bioconjugation(Protein : Engineering,The 48th Annual Meeting of the Biophysical Society of Japan)

, 2010
Hideaki Sanada, Mitsuo Umetsu, Ryutaro Asano, Izumi Kumagai   +3 more
openalex   +2 more sources

Engineering a human IgG2 antibody stable at low pH [PDF]

, 2020
Seiji Saito, Hiroshi Namisaki, Keiko Hiraishi, Nobuaki Takahashi, Shigeru Iida   +4 more
openalex   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Affinity Maturation for Antibody Engineering: The Critical Role of Residues on CDR Loops of Antibodies in Antigen Binding. [PDF]

Molecules
Yoshida M, Oda M.
europepmc   +1 more source

Engineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance [PDF]

, 2018
Saori Suzuki, Hiroaki Annaka, S. KONNO, Izumi Kumagai, Ryutaro Asano   +4 more
openalex   +1 more source

Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody [PDF]

, 2020
Chiara Modica, Simona Gallo, Cristina Chiriaco, Martina Spilinga, Paolo M. Comoglio, Tiziana Crepaldi, Cristina Basilico, Elisa Vigna   +7 more
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Next generation of multispecific antibody engineering. [PDF]

Antib Ther
Keri D, Walker M, Singh I, Nishikawa K, Garces F.   +4 more
europepmc   +1 more source