Results 231 to 240 of about 275,929 (307)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
A cell-free antibody engineering platform rapidly generates SARS-CoV-2 neutralizing antibodies
, 2020 Chen X, Gentili M, Hacohen N, Regev A.
europepmc +1 more source
Computationally driven antibody engineering enables simultaneous humanization and thermostabilization. [PDF]
Protein Eng Des Sel, 2016 Choi Y +3 more
europepmc +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Effects of N-Glycan Composition on Structure and Dynamics of IgG1 Fc and Their Implications for Antibody Engineering. [PDF]
Sci Rep, 2017 Lee HS, Im W.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Beyond antibody engineering: directed evolution of alternative binding scaffolds and enzymes using yeast surface display. [PDF]
Microb Cell Fact, 2018 Könning D, Kolmar H.
europepmc +1 more source
Arthritis Care &Research, EarlyView.Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie +3 more
wiley +1 more source
Antibody engineering for increased potency, breadth and half-life. [PDF]
Curr Opin HIV AIDS, 2015 Sievers SA +3 more
europepmc +1 more source