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Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper
Molecular Therapy - Methods and Clinical Development, 2022 Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with host immune responses against ...
John Kamerud +2 more
exaly +3 more sources
Predicting HLA CD4 Immunogenicity in Human Populations
Frontiers in Immunology, 2018 BackgroundPrediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications.
Sandeep Kumar Dhanda +2 more
exaly +3 more sources
Journal of Pharmaceutical Analysis, 2022 Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers.
Kevin McKinski +5 more
doaj +1 more source
Sleep and vaccine administration time as factors influencing vaccine immunogenicity [PDF]
Kosin Medical Journal, 2022 The immunogenicity of vaccines is affected by host, external, environmental, and vaccine factors; in addition, sleep or circadian rhythms may also have effects.
Eun Seok Kim, Chi Eun Oh
doaj +1 more source
Frontiers in Medicine, 2022 Cell and Gene Therapy Products (CGT), regulated as Advanced Therapy Medicinal Products (ATMP) in the European Union (EU), represent a novel and varied group of biotherapeutics developed to treat specific conditions for which there are limited or no ...
Laura I. Salazar-Fontana +2 more
doaj +1 more source
Scientific Reports, 2021 The major histocompatibility complex II (HLA-II) facilitates the presentation of antigen-derived peptides to CD4+ T-cells. Antigen presentation is not only affected by peptide processing and intracellular trafficking, but also by mechanisms that govern ...
A. Casasola-LaMacchia +6 more
doaj +1 more source
Immunogenicity of sulfatide [PDF]
Immunochemistry, 1977 Abstract The present study deals with the immunogenicity of sulfatide. Despite its acidic character, we succeeded in raising high titer antibodies. The most effective immunization procedure involved repeated intravenous injections of a mixture of sulfatide-lecithin-cholesterol-methylated bovibe serum albumin (1:4:10:10).
Zalc, B. +3 more
openaire +3 more sources
10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
mAbs, 2020 Therapeutic proteins and emerging gene and cell-based therapies are attractive therapeutic tools for addressing unmet medical needs or when earlier conventional treatment approaches failed.
S. Tourdot +17 more
doaj +1 more source
Immunogenicity of biopharmaceuticals [PDF]
Nephrology Dialysis Transplantation, 2006 The availability of biopharmaceuticals has been increasing over the past decade and as their patents expire, the emergence of biosimilar agents approaches. The primary issue of concern for the safety of these agents is the potential for immunogenicity.
Michele, Kessler +2 more
openaire +2 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2023 Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and safety.
Linnea C. Franssen +5 more
doaj +1 more source