Results 1 to 10 of about 66,232 (237)

10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals

mAbs, 2020
Therapeutic proteins and emerging gene and cell-based therapies are attractive therapeutic tools for addressing unmet medical needs or when earlier conventional treatment approaches failed.
S. Tourdot, A. Abdolzade-Bavil, J. Bessa, P. Broët, A. Fogdell-Hahn, M. Giorgi, V. Jawa, K. Kuranda, N. Legrand, S. Pattijn, J. A. Pedras-Vasconcelos, A. Rudy, P. Salmikangas, D. W. Scott, V. Snoeck, N. Smith, S. Spindeldreher, D. Kramer   +17 more
doaj   +2 more sources

Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

Molecular Therapy - Methods and Clinical Development, 2022
Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with host immune responses against ...
Tong-Yuan Yang, John Kamerud, Kay-Gunnar Stubenrauch   +2 more
exaly   +3 more sources

Proceedings of the 15th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals

mAbs
The European Immunogenicity Platform (EIP) celebrated the 15th edition of its Open Symposium on Immunogenicity of Biopharmaceuticals and its associated one-day workshop on 22–24 February 2024 in Lisbon.
Sophie Tourdot, Karien Bloem, Lysie Champion, Anne S. De Groot, Axel Ducret, Patrick Garidel, Joanna Grudzinska-Goebel, Michael Gutknecht, Timothy Hickling, Frank Horling, Marina Ichetovkin, Alison Johnson, Issa Jyamubandi, Anette Karle, Arno Kromminga, Ebru Aydin Kurtulmus, Floris Loeff, Bernard Maillere, Lydia Michaut, Francesca Minelli, Morten Nielsen, Vivek Nayak, Robert Nelson, Marc Pallardy, Sofie Pattyn, Joao Pedras-Vasconelos, Elise Pepermans, Alain Poyau, Matthias Reichel, Amy Rosenberg, Zuben Sauna, Manisha Saxena, Noel Smith, Veerle Snoeck, Lester Thoo, Michael Tovey, Daniela Verthelyi, Rene Wuttke, Daniel Yerly, Daniel Kramer   +39 more
doaj   +2 more sources

Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

Journal of Pharmaceutical Analysis, 2022
Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers.
Kevin McKinski, Dean McNulty, Francesca Zappacosta, Mary Birchler, Matt Szapacs, Christopher Evans   +5 more
doaj   +1 more source

Sleep and vaccine administration time as factors influencing vaccine immunogenicity [PDF]

Kosin Medical Journal, 2022
The immunogenicity of vaccines is affected by host, external, environmental, and vaccine factors; in addition, sleep or circadian rhythms may also have effects.
Eun Seok Kim, Chi Eun Oh
doaj   +1 more source

A Regulatory Risk-Based Approach to ATMP/CGT Development: Integrating Scientific Challenges With Current Regulatory Expectations

Frontiers in Medicine, 2022
Cell and Gene Therapy Products (CGT), regulated as Advanced Therapy Medicinal Products (ATMP) in the European Union (EU), represent a novel and varied group of biotherapeutics developed to treat specific conditions for which there are limited or no ...
Laura I. Salazar-Fontana, Laura I. Salazar-Fontana, Laura I. Salazar-Fontana   +2 more
doaj   +1 more source

Immunogenicity of allogeneic mouse mesenchymal stem cells (MSC) [PDF]

, 2012
Adult mesenchymal stem cells (MSC) are multipotential cells which can differentiate into various cell types thus giving them utility in tissue engineering regenerative medicine and cell-based therapies.
Mukonoweshuro, Blessing
core   +6 more sources

Human leukocyte antigen class II quantification by targeted mass spectrometry in dendritic-like cell lines and monocyte-derived dendritic cells

Scientific Reports, 2021
The major histocompatibility complex II (HLA-II) facilitates the presentation of antigen-derived peptides to CD4+ T-cells. Antigen presentation is not only affected by peptide processing and intracellular trafficking, but also by mechanisms that govern ...
A. Casasola-LaMacchia, M. S. Ritorto, R. J. Seward, N. Ahyi-Amendah, A. Ciarla, T. P. Hickling, H. Neubert   +6 more
doaj   +1 more source

Development of methods for the in-vitro assessment of the adipogenesis and immunogenicity of human multipotent mesenchymal stromal cells [PDF]

, 2011
Adult mesenchymal stromal cells (MSCs) have enormous potential in tissue engineering and regenerative medicine applications. MSC have also been reported to be immune-privileged.
Aldridge, Andrew Robert
core   +6 more sources

German experimental hepatitis B vaccine: influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers [PDF]

, 1986
Krämer A, Sommer D, Hahn EG, Riecken E-O. German experimental hepatitis B vaccine: influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers. Klinische Wochenschrift.
Sommer, D., Riecken, Ernst-Otto, Krämer, Alexander ; https://orcid.org/, Hahn, E. G.   +3 more
core   +1 more source