Results 21 to 30 of about 66,232 (237)

Taking immunogenicity assessment of therapeutic proteins to the next level [PDF]

, 2011
Therapeutic proteins provide innovative and effective therapies for numerous diseases. However, some of these products are associated with unwanted immunogenicity that may lead to clinical consequences such as reduced or loss of efficacy, altered ...
Mire-Sluis, A, Subramanyam, M., T. Platts-Mills, Stas, P., Krause, R, Reipert, BM, R. Krause, Trouvin, JH, J. Windisch, Jefferis, R., D. Kramer, Schellekens, H., Thorpe, R, F. Ehmann, Lubiniecki, A., Buttel, I.C., P. Chamberlain, Sub Biotechnological drugs, Platts-Mills, T, Kramer, D, R. Seitz, Weise, M., Stas, P, Ragheb, J.A., Chowers, Y, P. Stas, Windisch, J., Kramer, D., Schneider, CK, Greinacher, A., Lloyd, P, A. Greinacher, Windisch, J, J.A. Ragheb, Ehmann, F., Seitz, R., R. Jefferis, Reipert, B.M., A. Mire-Sluis, Pharmaceutics, H. Schellekens, M. Weise, Buettel, IC, Chowers, Y., C.K. Schneider, Ragheb, JA, Greinacher, A, Kropshofer, H, M. Subramanyam, Schneider, C.K., Lubiniecki, A, Mire-Sluis, A., J.-H. Trouvin, H. Kropshofer, Innovation Studies, R. Thorpe, Kropshofer, H., Lloyd, P., Seitz, R, Ehmann, F, P. Lloyd, Subramanyam, M, Weise, M, Y. Chowers, Jefferis, Royston, Thorpe, R., A. Lubiniecki, Chamberlain, P., Krause, R., I.C. Büttel, Trouvin, J.H., B.M. Reipert, Platts-Mills, T., Chamberlain, P, Schellekens, H   +74 more
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In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers [PDF]

, 2011
10.08.12 KB OA publisher, published version ok to add to Spiral.
Schmidt, C, Lorna Clark, Arlene Hurley, Kopycinski Jakub T., David D. Ho, Caskey, M, Clark, L, Hannaman, D, Gilmour Jill, Schlesinger, SJ, Cheeseman Hannah, Hurley Arlene, Smith Carol, Hurley, A, Ho, DD, Cheeseman, H, Ho David D., Caskey Marina, Fast Patricia, Dally, L, Marina Caskey, Gill Dilbinder K., Roselle Vittorino, Vasan, S, Sarah J Schlesinger, Andersen, J, Harriet H Park, Patricia Fast, Bernard Robert, Clark Lorna, Vittorino, R, Gardiner David F., Josephine H Cox, Dilbinder K. Gill, Dally Len, Robert Bernard, Vasan Sandhya, Josephine H. Cox, Jill Gilmour, Claudia Schmidt, Andersen Johanne, Johanne Andersen, Jakub T Kopycinski, Park Harriet H., Cox, JH, Smith, C, David F Gardiner, Gilmour, J, Harriet H. Park, Tony Tarragona-Fiol, Huang Yaoxing, Sarah J. Schlesinger, Len Dally, Gill, DK, Dilbinder K Gill, Cox Josephine H., Bernard, R, Boente-Carrera, M, Boente-Carrera Mar, Hannah Cheeseman, Sandhya Vasan, Carol Smith, Schlesinger Sarah J., Fast, P, Park, HH, Drew Hannaman, Schmidt Claudia, Tarragona-Fiol, T, Kopycinski, JT, Jakub T. Kopycinski, Huang, Y, Mar Boente-Carrera, Gardiner, DF, Yaoxing Huang, Hannaman Drew, Tarragona-Fiol Tony, Dugin, DP, Daniel P. Dugin, Daniel P Dugin, Vittorino Roselle, Dugin Daniel P., David D Ho, David F. Gardiner   +82 more
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Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines [PDF]

, 2011
The hemagglutinins (HAs) of human H1 and H3 influenza viruses and avian H5 influenza virus were produced as recombinant fusion proteins with the human immunoglobulin Fc domain.
Temperton, Nigel J., Ian M. Jones, Christopher R. Bailey, Eleonora Molesti, Ren, Junyuan, Jones, Ian M., Temperton, Nigel J, Silvia Loureiro, Pongsathon Phapugrangkul, Junyuan Ren, Wendy S. Barclay, Camilo A. Colaco, Molesti, Eleonora, Barclay, Wendy S., Shelton, Holly, Colaco, Camilo A, Phapugrangkul, Pongsathon, Nigel J. Temperton, Loureiro, Silvia, Barclay, Wendy S, Bailey, Christopher R, Holly Shelton, Jones, Ian, Colaco, Camilo A., Bailey, Christopher R.   +24 more
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Comprehensive biomarker analysis from phase II study of nivolumab in patients with thymic carcinoma

Frontiers in Oncology, 2023
In a phase II trial of nivolumab in advanced thymic carcinoma (UMIN000022007), long SD (SD for more than 24 weeks) was seen in three patients and irAE (Gr2 or higher) was seen in four patients among 15 patients.
Yuki Katsuya, Yuki Katsuya, Shigehisa Kitano, Makiko Yamashita, Mayu Ouchi, Shigehiro Yagishita, Akinobu Hamada, Akinobu Hamada, Hiromi Nakamura, Fumie Hosoda, Tatsuhiro Shibata, Noriko Motoi, Noriko Motoi, Takayuki Nakayama, Takashi Seto, Shigeki Umemura, Yukio Hosomi, Miyako Satouchi, Makoto Nishio, Toshiyuki Kozuki, Toyoaki Hida, Toyoaki Hida, Yuichiro Ohe, Hidehito Horinouchi   +23 more
doaj   +1 more source

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials [PDF]

, 2007
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second
Whelan, KT, Pathan, Ansar A, Poulton Ian, Nicola C Alder, Sander Clare R., Whelan, Kathryn T, Kathryn T Whelan, Hill, Adrian, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Alder, NC, Fletcher, HA, Pathan Ansar A., Hill, Adrian VS, Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Hill, AV, Beveridge, NER, Alder, Nicola C, Clare R Sander, Helen McShane, Ansar A Pathan, Beveridge, NE, Ian Poulton, Poulton, Ian, Alder Nicola C., Whelan Kathryn T., Poulton, I, Sander, Clare R, Adrian V S Hill, Helen A Fletcher, Fletcher Helen A., McShane, H, Beveridge, Natalie ER, Fletcher, Helen, McShane, Helen   +39 more
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Predicting HLA CD4 Immunogenicity in Human Populations

Frontiers in Immunology, 2018
BackgroundPrediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications.
Sandeep Kumar Dhanda, Edita Karosiene, Lindy Edwards, Alba Grifoni, Sinu Paul, Massimo Andreatta, Daniela Weiskopf, John Sidney, Morten Nielsen, Morten Nielsen, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +13 more
doaj   +1 more source

Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation

Frontiers in Bioengineering and Biotechnology, 2023
CRISPR offers new hope for many patients and promises to transform the way we think of future therapies. Ensuring safety of CRISPR therapeutics is a top priority for clinical translation and specific recommendations have been recently released by the FDA.
Radwa Ewaisha, Radwa Ewaisha, Karen S. Anderson   +2 more
doaj   +1 more source

T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. [PDF]

, 2011
BACKGROUND: The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa.
Osei-Kwakye, Kingsley, Emmanuel Asafo-Adjei, Patrice Dubois, Agbenyega, Tsiri, Janssens, Michel H, Apanga, Stephen, Adjei, George, Daniel Ansong, Dubois, Patrice, Janssens Michel H., Marc J J Lievens, Apanga Stephen, Owusu-Agyei Seth, Dubois Patrice, Greenwood Brian M., Brian M Greenwood, Ansong Daniel, Sylverken, Justice, Joe Cohen, Barbara M. Savarese, Vekemans Johan, Kwadwo O. Boahen, Owusu-Agyei, Seth, Alex Osei-Akoto, Naana A W Brobby, Kayan, Kingsley, Olivier, Aurelie C, Olivier Aurelie C., Owusu, Sandra K, Jongert, Erik, Lievens, Marc JJ, Antwi, Sampson, Owusu Ruth, Kwadwo O Boahen, Kingsley Kayan, Jongert Erik, Naana A. W. Brobby, Dosoo David, Savarese Barbara M., Philippe J. Moris, Kwaku P Asante, Philippe J Moris, Evans Jennifer A., Brian M. Greenwood, Stephen Apanga, Marc J. J. Lievens, Greenwood, Brian M, Michel H Janssens, Savarese, Barbara M, Sandra K. Owusu, Owusu, Ruth, Sandra K Owusu, Cohen Joe, Erik Jongert, George Adjei, Aurelie C. Olivier, Asante Kwaku P., Osei-Akoto Alex, Justice Sylverken, Jennifer A. Evans, Brobby Naana A. W., Agbenyega Tsiri, Moris Philippe J., Boahen, Kwadwo O, Cohen, Joe, Kayan Kingsley, Sampson Antwi, Sambian, David, Asante, Kwaku P, Asafo-Adjei Emmanuel, Sylverken Justice, Ansong, Daniel, Barbara M Savarese, Boahen Kwadwo O., Adjei George, Osei-Kwakye Kingsley, Kingsley Osei-Kwakye, Asafo-Adjei, Emmanuel, David Sambian, Sambian David, Moris, Philippe J, David Dosoo, Ruth Owusu, Kwaku P. Asante, Lievens Marc J. J., Vekemans, Johan, Tsiri Agbenyega, Brobby, Naana AW, Osei-Akoto, Alex, Aurelie C Olivier, Dosoo, David, Jennifer A Evans, Owusu Sandra K., Seth Owusu-Agyei, Michel H. Janssens, Antwi Sampson, Johan Vekemans, Evans, Jennifer A   +97 more
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Safety, immunogenicity and duration of protection of a candidate malaria vaccine in Mozambique / Seguridad, inmunogenicidad y duración de protección del candidato a vacuna contra la malaria en Mozambique [PDF]

, 2011
Malaria, caused by Plasmodium falciparum parasites remains a huge public health problem and a major cause of morbidity and mortality in sub-Saharan Africa, especially among children and infants.
Aide, Pedro Carlos Paulino
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Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif [PDF]

, 2014
Protein α-helical coiled coil structures that elicit antibody responses, which block critical functions of medically important microorganisms, represent a means for vaccine development.
Kajava, Andrey V., Catherine Habel (587966), Ingrid Felger (92160), Andrey V. Kajava (87242), Myriam Arévalo-Herrera (2576233), Herrera, Sócrates, Catherine Habel, Felger, Ingrid, Corradin, Giampietro, Angélica Castellanos (587967), Moret, Remy, Ingrid Felger, Giampietro Corradin (27387), Sócrates Herrera, Angélica Castellanos, Myriam Arévalo-Herrera, Catherine Servis (273314), Mary Lopez-Perez (123279), Mary Lopez-Perez, Habel, Catherine, Céspedes, Nora, Servis, Catherine, Andrey V Kajava, Sócrates Herrera (2576236), Castellanos, Angélica, Arévalo-Herrera, Myriam, Giampietro Corradin, Remy Moret (587968), Nora Céspedes (587965), Remy Moret, Lopez-Perez, Mary, Catherine Servis, Nora Céspedes   +32 more
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