Results 31 to 40 of about 238,930 (305)

Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study

, 2010
Objectives: To compare the safety, reactogenicity, and immunogenicity of an adjuvanted split virion H1N1 vaccine and a non-adjuvanted whole virion vaccine used in the pandemic immunisation programme in the United Kingdom.
Sheasby, E, Faust, S N, Okike, I, Miller, E., Casey, M., Walker, W T, Sheasby, E., Waight, P., Ladhani, S., Allen, R.J., Andrews, N, Eccleston, P.E., Faust, S.N., Oeser, C, John, T, Snape, MD, Pollard, AJ, Pollard, Andrew, Finn, A., Casey, M, Waddington, CS, Heath, PT, Heath, P.T., Collinson, AC, Eccleston, P E, Waddington, Claire S, Wilkins, S, Allen, R J, Faust, SN, Walker, W.T., Reiner, A, Ladhani, S, Collinson, A.C., Okike, I., Reiner, A., Waddington, Claire S., Miller, E, Andrews, N., Allen, RJ, Finn, A, Wilkins, S., Snape, M.D., Pollard, A.J., Eccleston, PE, Collinson, A C, Walker, WT, Heath, P T, Snape, M D, Hoschler, K., John, T., Hoschler, K, Waight, P, Oeser, C.   +52 more
core   +1 more source

Coronavirus immunogens

Veterinary Microbiology, 1993
Coronaviruses (CV) infect a variety of livestock, poultry and companion animals. They belong to at least five antigenic groups. CV cause localized infections of the respiratory and/or intestinal tracts, with the exception of feline infectious peritonitis virus (FIPV) and hemagglutinating encephalomyelitis (HEV) which cause systemic infections.
openaire   +2 more sources

Immunogenicity profile.

, 2022
Immunogenicity profile.
Andrey L. Bakulev (5727509), Alkes A. Khotko (12054833), Vladislav R. Khairutdinov (10681905), Irina V. Chumachenko (12054839), Valery V. Dubenskiy (12054827), Tat’yana V. Korotaeva (12054818), Antonina V. Artemeva (10681912), Alexey V. Samtsov (10681904), Alexander M. Lukyanov (12054842), Bulat V. Khalilov (12054830), Muza M. Kokhan (10681903), Iskander K. Minullin (12054821), Polina P. Pukhtinskaia (12054845), Olga A. Vylegzhanina (12054824), Olga S. Zykova (12054836)   +14 more
core   +1 more source

Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity. [PDF]

, 2022
In this study we show that glycosylation is relevant for immune recognition of therapeutic antibodies, and that defined glycan structures can modulate immunogenicity.
Michael Kammüller, Isabelle Beley, Cordier, Valerie, Schindler, Patrick, Patoux, Agnes, Agnes Patoux, Brees, Dominique, Mateusz Piksa, Valerie Cordier, Stöllner, Daniela, Babette Wolf, von Gunten, Stephan, Bernd Voedisch, Dominique Brees, Patrick Schindler, Besson, Thierry, Daniela Stöllner, Kammueller, Michael, Ludovic Perrot, Stephan von Gunten, Beley, Isabelle, Kammüller, Michael, Wolf, Babette, Thierry Besson, Voedisch, Bernd, Perrot, Ludovic, Piksa, Mateusz   +26 more
core   +1 more source

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform

Frontiers in Immunology
In vitro and in silico tools help drug developers reduce unwanted immunogenicity of biologics at the design stage. These include assays that examine different immune system processes leading to anti-drug antibody (ADA) or cytotoxic cellular response ...
Sophie Tourdot, Anette Christine Karle, Marc Rosenbaum, Chloé Ackaert, Pauline Le Vu, Michael Gutknecht, Maryam Ahmadi, Annelies W. Turksma, Timothy P. Hickling   +8 more
doaj   +1 more source

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A [PDF]

, 2013
© 2013 Matsumiya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Helen McShane (80704), Pathan, Ansar A, Stylianou, E, Lang, Z, Stephanie A. Harris (429956), Elena Stylianou (292312), Matsumiya, Magali, Griffiths Kristin, Lang Zoe, McShane Helen, Meyer, Joel, Magali Matsumiya, Griffiths, Kristin, Zoe Lang (429954), Lang, Zoe, Ansar A Pathan, Meyer, J, Angela M. Minassian (345365), Magali Matsumiya (429952), Fletcher Helen, Harris, Stephanie A, Rowland Rosalind, Meyer Joel, Kristin Griffiths (429953), Joel Meyer, Harris, SA, McShane, H, Fletcher, Helen, McShane, Helen, Minassian, Angela M, Zoe Lang, Rowland, Rosalind, Matsumiya Magali, Minassian Angela M., Angela M Minassian, Kristin Griffiths, Pathan Ansar A., Joel Meyer (429955), Helen Fletcher, Harris Stephanie A., Rowland, R, Rosalind Rowland, Matsumiya, M, Pathan, AA, Fletcher, H, Minassian, AM, Helen Fletcher (249210), Rosalind Rowland (429957), Helen McShane, Griffiths, K, Elena Stylianou, Stephanie A Harris, Ansar A. Pathan (80697), Stylianou, Elena, Stylianou Elena   +54 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Long-term humoral and cellular immune responses following Covaxin vaccination: a 2-year prospective longitudinal study

Frontiers in Immunology
BackgroundGlobally, multiple SARS-CoV-2 vaccines received emergency authorization, primarily based on adenoviral vector, mRNA, or inactivated virus platforms.
Archana Tripathy, Archana Tripathy, Sreeparna Podder, Sreeparna Podder, Swatishree Sradhanjali, Swatishree Sradhanjali, Mamuni Swain, Debdutta Bhattacharya, Debaprasad Parai, Sanghamitra Pati, Sunil K. Raghav, Sunil K. Raghav   +11 more
doaj   +1 more source

Immunogenicity and safety of vaccination in children with paediatric rheumatic diseases: a scoping review

, 2023
Children with paediatric rheumatic diseases (PRDs) are at increased risk of vaccine-preventable disease. Safe and effective vaccination is central to preventive care in PRD patients; however, uncertainty surrounding immunogenicity and safety has ...
Cunninghame, J, Cann, M, Wen, S, Dufficy, M, Doyle, R, Ullman, A, Takashima, M   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source