Results 31 to 40 of about 384,579 (350)

A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity [PDF]

, 2012
© 2012 Elsevier Ltd. All rights reservedBackground: The development of a new, more effective vaccine against tuberculosis (TB) for use in healthy and HIV-infected adults, children and infants, remains a global health priority.
Minassian, Angela M, Porter, David W, Pathan, Ansar A, Rowland, Rosalind, Sander, C, Satti, Iman, Angela M Minassian, Nicola Williams, Lawrie, AM, Sander, Clare, Alison M Lawrie, Rowland, R, Poulton, ID, Rosalind Rowland, Brittain, N, Williams, Nicola, Pathan, AA, David W Porter, Minassian, AM, Helen McShane, Iman Satti, Ansar A Pathan, Ian D Poulton, Lawrie, Alison M, Nathaniel Brittain, Williams, N, Brittain, Nathaniel, Poulton, Ian D, Clare Sander, Porter, DW, Satti, I, McShane, H, McShane, Helen   +32 more
core   +1 more source

Understanding the Supersensitive Anti-Drug Antibody Assay: Unexpected High Anti-Drug Antibody Incidence and Its Clinical Relevance

Journal of Immunology Research, 2016
Numbers of biotherapeutic products in development have increased over past decade. Despite providing significant benefits to patients with unmet needs, almost all protein-based biotherapeutics could induce unwanted immunogenicity, which result in a loss ...
Sam Song, Lili Yang, William L. Trepicchio, Timothy Wyant   +3 more
doaj   +1 more source

Learn–confirm in model‐informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform

CPT: Pharmacometrics & Systems Pharmacology, 2023
Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and safety.
Linnea C. Franssen, Maciej J. Swat, Andrzej M. Kierzek, Rachel H. Rose, Piet H. van derGraaf, Hans Peter Grimm   +5 more
doaj   +1 more source

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Nature Communications, 2021
The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd protection and control the spread of SARS-CoV-2.
Jing-hui Tian, N. Patel, Robert E. Haupt, Haixia Zhou, S. Weston, Holly Hammond, James Logue, A. Portnoff, James Norton, M. Guebre‐Xabier, Bin Zhou, K. Jacobson, Sonia Maciejewski, Rafia Khatoon, Małgorzata Wiśniewska, Will Moffitt, S. Kluepfel-Stahl, Betty Ekechukwu, James F. Papin, S. Boddapati, C. Jason Wong, P. Piedra, M. Frieman, M. Massare, L. Fries, K. Bengtsson, Linda Stertman, L. Ellingsworth, G. Glenn, Gale Smith   +29 more
semanticscholar   +1 more source

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Said, Khadija, Benjamin M Kagina, Willem A Hanekom, Nicole Lenz (671838), Hoff, Søren T., Fielding, Katherine L., Ingrid Kromann (370517), Khadija Said, Hannah Jeffery, Gardiner, Nicolene, Trevor Beattie (671836), Willem A. Hanekom (125097), Daubenberger, Claudia, Klaus Reither, Peter Andersen, Trevor Beattie, Fielding, Katherine L, Scriba, Thomas J, Hoff, Søren T, Søren T. Hoff (246744), Ingrid Kromann, Pohl, Christian, Klaus Reither (259897), Landay, Alan, Katsoulis, Lynn, Lynn Katsoulis, Scriba, Thomas J., Katherine L Fielding, Bang, Peter, Christian Pohl, Peter Bang (671842), Jeffery, Hannah, Peter Bang, Hannah Jeffery (671839), Nicolene Gardiner (671837), Elisabeth J. Hughes (671841), Claudia Daubenberger, Elirehema Mfinanga (476407), Elisabeth J Hughes, Søren T Hoff, Hughes, Elisabeth J., Gavin J. Churchyard (143332), Elirehema Mfinanga, Kagina, Benjamin M, Nicole Lenz, Benjamin M. Kagina (671840), Thomas J Scriba, Khadija Said (476408), Churchyard, Gavin J, Hanekom, Willem A., Mfinanga, Elirehema, Beattie, Trevor, Christian Pohl (476404), Kagina, Benjamin M., Andersen, Peter, Hanekom, Willem A, Reither, Klaus, Nicolene Gardiner, Thomas J. Scriba (76847), Claudia Daubenberger (212658), Lynn Katsoulis (671835), Kromann, Ingrid, Gavin J Churchyard, Hughes, Elisabeth J, Peter Andersen (88335), Churchyard, Gavin J., Lenz, Nicole, Katherine L. Fielding (143336)   +67 more
core   +1 more source

Immunogenicity and safety of vaccination in children with paediatric rheumatic diseases: a scoping review [PDF]

, 2023
Children with paediatric rheumatic diseases (PRDs) are at increased risk of vaccine-preventable disease. Safe and effective vaccination is central to preventive care in PRD patients; however, uncertainty surrounding immunogenicity and safety has ...
Cunninghame, J, Cann, M, Wen, S, Dufficy, M, Doyle, R, Ullman, A, Takashima, M   +6 more
core   +1 more source

Immunogenicity of Rhinoviruses

Experimental Biology and Medicine, 1970
SummaryUniformly successful production of rabbit rhinovirus antisera depended on production of immunogens with virus concentrations of at least 107 pfu/ml. Response in pairs of rabbits immunized with the same antigen appeared to be remarkably uniform, and maximum antibody titers were attained at 38 to 45 days after beginning a relatively simple ...
M K, Cooney, G E, Kenny
openaire   +2 more sources

Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

Experimental and Molecular Medicine, 2023
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to wield them in the development of therapeutics and vaccines.
Jisun Lee, M. Woodruff, Eui Ho Kim, J. Nam   +3 more
semanticscholar   +1 more source

Algorithm for optimized mRNA design improves stability and immunogenicity [PDF]

Nature, 2020
An algorithm based on concepts established in computational linguistics enables rapid principled design of mRNA vaccines optimizing both structural stability and codon usage, resulting in improved half-life, protein expression and immune responses ...
He Zhang, Liang Zhang, Ang Lin, Congcong Xu, Ziyu Li, Kaibo Liu, Boxiang Liu, Xiaopin Ma, Fanfan Zhao, Huiling Jiang, Chunxiu Chen, Haifa Shen, Hangwen Li, D. Mathews, Yujian Zhang, Liang Huang   +15 more
semanticscholar   +1 more source

Trastuzumab immunogenicity development in patients’ sera and in laboratory animals

BMC Immunology, 2021
Background Immunogenicity is a major challenge in drug development and patient care. Clinicians and regulators are familiar with immunogenicity concerns of monoclonal antibody (mAb) therapeutics, growth factors and enzyme replacements.
Lobna Abdel Aziz Kilany, Ayman Abdel Samie Gaber, Mohammad Mabrouk Aboulwafa, Hamdallah Hafez Zedan   +3 more
doaj   +1 more source