Results 11 to 20 of about 238,930 (305)

Proceedings of the 15th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals

mAbs
The European Immunogenicity Platform (EIP) celebrated the 15th edition of its Open Symposium on Immunogenicity of Biopharmaceuticals and its associated one-day workshop on 22–24 February 2024 in Lisbon.
Sophie Tourdot, Karien Bloem, Lysie Champion, Anne S. De Groot, Axel Ducret, Patrick Garidel, Joanna Grudzinska-Goebel, Michael Gutknecht, Timothy Hickling, Frank Horling, Marina Ichetovkin, Alison Johnson, Issa Jyamubandi, Anette Karle, Arno Kromminga, Ebru Aydin Kurtulmus, Floris Loeff, Bernard Maillere, Lydia Michaut, Francesca Minelli, Morten Nielsen, Vivek Nayak, Robert Nelson, Marc Pallardy, Sofie Pattyn, Joao Pedras-Vasconelos, Elise Pepermans, Alain Poyau, Matthias Reichel, Amy Rosenberg, Zuben Sauna, Manisha Saxena, Noel Smith, Veerle Snoeck, Lester Thoo, Michael Tovey, Daniela Verthelyi, Rene Wuttke, Daniel Yerly, Daniel Kramer   +39 more
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A randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children. [PDF]

, 2010
BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages.
Schultsz, C, To, S.D., Vinh Chau Nguyen Van, Dolecek, C., Thi Diem Ha Tran, Dolecek, Christiane, Nguyen, V.M.H., Van Vinh Chau Nguyen, Upton Anthony, Nguyen, T.D., Thi Dung Nguyen, James P May, Marques, F, Nguyen, T.T., Schultsz, Constance, Glover, Clare, Upton, A., Nguyen, Thi Cam Binh, Stockwell, E, Hoang Nguyen Van Minh, Schultsz, C., Farrar, Jeremy, Upton, A, Glover, C., Van Minh Hoang Nguyen, Nguyen, Thanh Truong, Filipe Marques, Nguyen, TCB, James P. May, Pham Van Toi, James I. Campbell, Stockwell, E., Pham, Van Toi, Elaine Stockwell, Nga Tran Thi Thu, Ninh, TTV, Tran, T.D.H., May, James P, James I Campbell, To, Song Diep, Nguyen, T.C.B., Toi Pham Van, Tran, Thi Thu Nga, May, J.P., Tran, TTN, Budhram, R., Tran, T.T.N., Simmons, Cameron P, Van Toi Pham, Tran, N.B.C., Lam, W., Glover Clare, Campbell, J.I., Marques, F., Ha Tran Thi Diem, Bich Chau Tran Nguyen, Tran, TDH, Nguyen, VVC, Campbell, JI, Ninh Thi Thanh Van, To, SD, Schultsz Constance, Dougan, Gordon, Ninh, Tran, Lam, Winnie, Nguyen, V.V.C., Campbell James I., Farrar Jeremy, Dolecek, C, Upton, Anthony, Christiane Dolecek, Cameron P. Simmons, Simmons, Cameron, Stockwell, Elaine, Tran, Tinh Hien, Ninh, Thi Thanh Van, Nguyen Thi Cam Binh, Budhram, Ronald, Nguyen Thi Dung, Dung Nguyen Thi, Hien Tran Tinh, Cao, Thu Thuy, Van Ninh Thi Thanh, Cao, T.T., Simmons, Cameron P., Constance Schultsz, Tran, NBC, Tran Tinh Hien, Stockwell Elaine, Nguyen, Van Minh Hoang, Dolecek Christiane, Tran, TH, Lam Winnie, Campbell, James I, Nguyen, Van Vinh Chau, Tran Thi Diem Ha, Nguyen, Thi Dung, Winnie Lam, Gordon Dougan, May James P., Farrar, J, Nguyen Bich Chau Tran, Nguyen, TC, Nguyen, TD, Jeremy Farrar, Tran, TT, Cao Thu Thuy, Tinh Hien Tran, Thi Thanh Van Ninh, Budhram, R, Pham, V.T., Thu Thuy Cao, Simmons, C.P., Nguyen, TT, Glover, C, Tran, TD, Thuy Cao Thu, Ninh, TT, Simmons, CP, May, James P., Dougan, G., Ronald Budhram, Pham, V.M., Thi Cam Binh Nguyen, Pham, Van Minh, Lam, W, Thanh Truong Nguyen, Nguyen Van Minh Hoang, Farrar, J., Van Minh Pham, Tran, Nguyen Bich Chau, Thi Thu Nga Tran, Song Diep To, Nguyen Thanh Truong, Dougan Gordon, Pham Van Minh, Cao, TT, Clare Glover, Nguyen Van Vinh Chau, To Song Diep, Ninh, T.T.V., Tran, NB, Nguyen, MV, Budhram Ronald, Tran Nguyen Bich Chau, Marques, Filipe, Campbell, James I., Tran, Thi Diem Ha, Simmons Cameron P., Binh Nguyen Thi Cam, Tran, T.H., Cameron P Simmons, Pham, VM, Nguyen, VM, Tran Thi Thu Nga, Marques Filipe, Pham, VT, Nguyen, VV, Minh Pham Van, May, JP, Dougan, G, Anthony Upton, Truong Nguyen Thanh   +162 more
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A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity [PDF]

, 2012
© 2012 Elsevier Ltd. All rights reservedBackground: The development of a new, more effective vaccine against tuberculosis (TB) for use in healthy and HIV-infected adults, children and infants, remains a global health priority.
Minassian, Angela M, Porter, David W, Pathan, Ansar A, Rowland, Rosalind, Sander, C, Satti, Iman, Angela M Minassian, Nicola Williams, Lawrie, AM, Sander, Clare, Alison M Lawrie, Rowland, R, Poulton, ID, Rosalind Rowland, Brittain, N, Williams, Nicola, Pathan, AA, David W Porter, Minassian, AM, Helen McShane, Iman Satti, Ansar A Pathan, Ian D Poulton, Lawrie, Alison M, Nathaniel Brittain, Williams, N, Brittain, Nathaniel, Poulton, Ian D, Clare Sander, Porter, DW, Satti, I, McShane, H, McShane, Helen   +32 more
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Immunogenicity of autoantigens [PDF]

BMC Genomics, 2011
Autoantibodies against self-antigens have been associated not only with autoimmune diseases, but also with cancer and are even found in healthy individuals. The mechanism causing the autoantibody response remains elusive for the majority of the immunogenic antigens. To deepen the understanding of autoantibody responses, we ask whether natural-occurring,
Keller Andreas, Hoffmann Jana, Harz Christian, Leidinger Petra, Ludwig Nicole, Backes Christina, Meese Eckart, Lenhof Hans-Peter   +7 more
openaire   +3 more sources

Understanding the Supersensitive Anti-Drug Antibody Assay: Unexpected High Anti-Drug Antibody Incidence and Its Clinical Relevance

Journal of Immunology Research, 2016
Numbers of biotherapeutic products in development have increased over past decade. Despite providing significant benefits to patients with unmet needs, almost all protein-based biotherapeutics could induce unwanted immunogenicity, which result in a loss ...
Sam Song, Lili Yang, William L. Trepicchio, Timothy Wyant   +3 more
doaj   +1 more source

Trastuzumab immunogenicity development in patients’ sera and in laboratory animals

BMC Immunology, 2021
Background Immunogenicity is a major challenge in drug development and patient care. Clinicians and regulators are familiar with immunogenicity concerns of monoclonal antibody (mAb) therapeutics, growth factors and enzyme replacements.
Lobna Abdel Aziz Kilany, Ayman Abdel Samie Gaber, Mohammad Mabrouk Aboulwafa, Hamdallah Hafez Zedan   +3 more
doaj   +1 more source

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Said, Khadija, Benjamin M Kagina, Willem A Hanekom, Nicole Lenz (671838), Hoff, Søren T., Fielding, Katherine L., Ingrid Kromann (370517), Khadija Said, Hannah Jeffery, Gardiner, Nicolene, Trevor Beattie (671836), Willem A. Hanekom (125097), Daubenberger, Claudia, Klaus Reither, Peter Andersen, Trevor Beattie, Fielding, Katherine L, Scriba, Thomas J, Hoff, Søren T, Søren T. Hoff (246744), Ingrid Kromann, Pohl, Christian, Klaus Reither (259897), Landay, Alan, Katsoulis, Lynn, Lynn Katsoulis, Scriba, Thomas J., Katherine L Fielding, Bang, Peter, Christian Pohl, Peter Bang (671842), Jeffery, Hannah, Peter Bang, Hannah Jeffery (671839), Nicolene Gardiner (671837), Elisabeth J. Hughes (671841), Claudia Daubenberger, Elirehema Mfinanga (476407), Elisabeth J Hughes, Søren T Hoff, Hughes, Elisabeth J., Gavin J. Churchyard (143332), Elirehema Mfinanga, Kagina, Benjamin M, Nicole Lenz, Benjamin M. Kagina (671840), Thomas J Scriba, Khadija Said (476408), Churchyard, Gavin J, Hanekom, Willem A., Mfinanga, Elirehema, Beattie, Trevor, Christian Pohl (476404), Kagina, Benjamin M., Andersen, Peter, Hanekom, Willem A, Reither, Klaus, Nicolene Gardiner, Thomas J. Scriba (76847), Claudia Daubenberger (212658), Lynn Katsoulis (671835), Kromann, Ingrid, Gavin J Churchyard, Hughes, Elisabeth J, Peter Andersen (88335), Churchyard, Gavin J., Lenz, Nicole, Katherine L. Fielding (143336)   +67 more
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Immunogenicity of Rhinoviruses

Experimental Biology and Medicine, 1970
SummaryUniformly successful production of rabbit rhinovirus antisera depended on production of immunogens with virus concentrations of at least 107 pfu/ml. Response in pairs of rabbits immunized with the same antigen appeared to be remarkably uniform, and maximum antibody titers were attained at 38 to 45 days after beginning a relatively simple ...
M K, Cooney, G E, Kenny
openaire   +2 more sources

Properties of MHC class I presented peptides that enhance immunogenicity. [PDF]

PLoS Computational Biology, 2013
T-cells have to recognize peptides presented on MHC molecules to be activated and elicit their effector functions. Several studies demonstrate that some peptides are more immunogenic than others and therefore more likely to be T-cell epitopes. We set out
Jorg J A Calis, Matt Maybeno, Jason A Greenbaum, Daniela Weiskopf, Aruna D De Silva, Alessandro Sette, Can Keşmir, Bjoern Peters   +7 more
doaj   +1 more source

Randomized, Controlled Trial of the Long Term Safety, Immunogenicity and Efficacy of RTS,S/AS02(D) Malaria Vaccine in Infants Living in a Malaria-Endemic Region. [PDF]

, 2013
The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization.
Machera, Francisca, Abdulla, Salim, Tanner, M., Schellenberg David, Vekemans, J., Richard Kamata, Kamata, Richard, Grace Mwangoka, Kubhoja, S., Leach, Amanda, Villafana Tonya, Dubois Marie-Claude, Sulende Kubhoja, Carter, T, Carter Terrell, Villafana, T, Dubois, M-C, Salim Nahya, Mshinda, H, Dubois, Marie-Claude, Leach, A, Joe Cohen, Salim, N, Kubhoja, Sulende, Vekemans Johan, Salim Abdulla, Mwangoka, G, Carter, T., Juma, O., Mohammed, A., Marcel Tanner, Marie-Claude Dubois, Mshinda Hassan, Marc Lievens, Aebi, Thomas, Kamata, R., Nahya Salim, Ballou, W Ripley, Machera, F., Leach, A., Lievens, Marc, Mohammed Ali, Leach Amanda, Ballou, W. R., W Ripley Ballou, Abdulla, S, Amanda Leach, Kubhoja Sulende, Cohen Joe, Ali Mohammed, Mwangoka Grace, Lievens Marc, Salim, N., Cohen, J., Hassan Mshinda, Abdulla, S., Mohammed, A, Aebi, T, Shomari, M, Mwangoka, G., Schellenberg, D, Cohen, Joe, Schellenberg, D., Machera Francisca, Tanner Marcel, Abdulla Salim, Tanner, M, Carter, Terrell, Juma, Omar, Ballou W Ripley, Omar Juma, Machera, F, Shomari, Mwanajaa, Aebi, T., Schellenberg, David, Mwanajaa Shomari, Lievens, M, Cohen, J, Thomas Aebi, Lievens, M., Juma Omar, Vekemans, J, Juma, O, Vekemans, Johan, Mshinda, Hassan, Tanner, Marcel, Shomari Mwanajaa, Mwangoka, Grace, David Schellenberg, Francisca Machera, Villafana, T., Shomari, M., Mshinda, H., Terrell Carter, Salim, Nahya, Mohammed, Ali, Dubois, M. C., Ballou, WR, Tonya Villafana, Kamata Richard, Kubhoja, S, Aebi Thomas, Johan Vekemans, Kamata, R, Villafana, Tonya   +104 more
core   +1 more source