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Antibody engineering for therapeutics
Current Opinion in Structural Biology, 2003With the acceptance of antibodies as therapeutics, a diversity of engineered antibody forms have been created to improve their efficacy, including enhancing the effector functions of full-length antibodies, delivering toxins to kill cells or cytokines in order to stimulate the immune system, and bispecific antibodies to target multiple receptors. After
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Biotechnology and Bioprocess Engineering, 2002
Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975. In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders.
Hyo Jeong Hong, Sun Taek Kim
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Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975. In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders.
Hyo Jeong Hong, Sun Taek Kim
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Engineering monoclonal antibodies
Nature, 1989Efforts to alter the mAb component of pharmaceuticals have focused on making them more human-lIke and smaller. Ultimately, the smallest molecular recognition unit derived from antibodies may be a single complementarity region.
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Engineering Antibodies for Biosensor Technologies
2005Publisher Summary The emphasis of this chapter is directed towards the progress made using genetically engineered antibodies that could provide solutions to many of the problems currently associated with the use of conventional antibodies in biosensor systems.
Sarah, Goodchild +3 more
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Protein Engineering of Antibodies
Critical Reviews in Biotechnology, 1992This article reviews the technical advances in antibody engineering and the clinical applications of these molecules. Recombinant DNA technology facilitates the construction and expression of engineered antibodies. These novel molecules are designed to meet specific applications.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
exaly
Genetically engineered antibodies
Immunology Today, 1985M A, Boss, C R, Wood
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