Results 101 to 110 of about 1,554,946 (301)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
THE STUDY OF IMMUNOTOXIC PROPERTIES OF AVERSECT FORTE AND AVERSECT COMBI
Российский паразитологический журнал, 2016 Objective of research: Determination of possible immunotoxic properties of Aversect Forte (Ivermectin + Abamectin) and Aversect Combi (Ivermectin + Aversectin С).
M. V. Semenova, K. G. Kurochkina
doaj
Effect of leukocyte-reduced platelet transfusion on the production of HLA antibodies in patients
Zhongguo shuxue zazhi[Objective] To investigate the factors associated with HLA antibody formation in patients undergoing platelet transfusion and to evaluate the intervention effect of leukocyte depletion technology.
LI Jixin, LI Shaowen
doaj +1 more source
Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. [PDF]
, 1994 Members of the TGF-beta superfamily appear to modulate mesenchymal differentiation, including the processes of cartilage and bone formation. Nothing is yet known about the function of the TGF-beta-related factor vgr-1, also called bone morphogenetic ...
Derynck, R +5 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Antisperm antibody formation following Vasectomy
Journal of Family and Reproductive Health, 2007 Objective: Seeking for fertility after previous vasectomy is increasing. Vasectomy may break the blood testis barrier and in this way the level of antisperm antibody increases.
Mohammad Reza Nowroozi +4 more
doaj
Cell Reports, 2018 Summary: Transitioning from a metabolically quiescent naive B cell to an antibody-secreting plasmablast requires division-dependent cellular differentiation.
Madeline J. Price +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion
Frontiers in Immunology, 2018 Red blood cell (RBC) alloimmunization represents a significant immunological challenge for some patients. While a variety of immune constituents likely contribute to the initiation and orchestration of alloantibodies to RBC antigens, identification of ...
Seema R. Patel +15 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source