Results 361 to 370 of about 10,530,811 (405)

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Pharmacological Reviews, 2004
The rationale fo the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug itself. In the last decades, numerous prodrugs that are enzymatically activated into anti-cancer agents have been developed.
Rooseboom, M., Commandeur, J.N.M., Vermeulen, N.P.E.   +2 more
openaire   +3 more sources

HIGHLY ACTIVE ANTICANCER CURCUMIN ANALOGUES

2007
Curcumin, a compound in the human food supply, represents a near-perfect starting point for drug discovery. Consequently, a number of research groups have taken the natural product as a starting point to prepare and biologically evaluate a wide variety of curcumin analogues.
Cara A, Mosley, Dennis C, Liotta, James P, Snyder   +2 more
openaire   +2 more sources

Indole alkaloids with potential anticancer activity.

Current Topics in Medicinal Chemistry, 2020
Indole alkaloids which are abundance in nature are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert the anticancer activity via various antiproliferative mechanisms, and some of them such as ...
Dan Xu, Zhi Xu
semanticscholar   +1 more source

Advances in Chalcones with Anticancer Activities

Recent Patents on Anti-Cancer Drug Discovery, 2014
Chalcones are naturally occurring compounds exhibiting broad spectrum biological activities including anticancer activity through multiple mechanisms. Literature on anticancer chalcones highlights the employment of three pronged strategies, namely; structural manipulation of both aryl rings, replacement of aryl rings with heteroaryl scaffolds ...
Chandrabose, Karthikeyan, Narayana S H Narayana, Moorthy, Sakthivel, Ramasamy, Uma, Vanam, Elangovan, Manivannan, Devarajan, Karunagaran, Piyush, Trivedi   +6 more
openaire   +2 more sources

Anticancer activity of novel indenopyridine derivatives

Archives of Pharmacal Research, 2012
Eighteen new 4-[2-amino-3-cyano-5-oxo-4-substitutedaryl-4H-indeno[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide derivatives 6a-q were synthesized via a reaction of aromatic aldehydes, enaminone 3 and malononitrile in one-pot reaction. Also, compounds 6a-q were obtained, via another route by reaction of enaminone 3 with arylidenemalononitriles 4a-q.
Mostafa M, Ghorab, Mansour S, Al-Said
openaire   +2 more sources

Anticancer activity of salicin and fenofibrate

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide.
Marwa, Sabaa, Hassan M, ELFayoumi, Shimaa, Elshazly, Mahmoud, Youns, Waleed, Barakat   +4 more
openaire   +2 more sources

Development of Oral Delivery Systems with Enhanced Antioxidant and Anticancer Activity: Coix Seed Oil and β-Carotene Coloaded Liposomes.

Journal of Agricultural and Food Chemistry, 2019
Fortifying food and beverage products with combinations of bioactive agents is a major initiative within the food industry because of their potentially additive or even synergistic benefits for human health.
Chunqing Bai, Jingxia Zheng, Li Zhao, Lili Chen, H. Xiong, D. Mcclements   +5 more
semanticscholar   +1 more source

Anticancer Activities of Tumor-killing Nanorobots

Trends in Biotechnology, 2019
Pharmaceutical uses of cancer therapeutics, such as intravenous thrombin to elicit blood coagulation, have been hampered by lack of tumor specificity. Based on rapid progress in DNA origami-based machines capable of transporting molecular payloads, DNA nanorobots have been constructed to specifically deliver therapeutic agents into tumor vessels.
Suping Li, Qiao Jiang, Baoquan Ding, Guangjun Nie   +3 more
openaire   +3 more sources

Anticancer activity of lactic acid bacteria.

Seminars in Cancer Biology, 2022
K. Garbacz
semanticscholar   +1 more source

Trees with Anticancer Activities

2017
Many trees are known to possess important anticancer compounds which include flavonoids and other phenolic compounds, glucosinolates, phytosterols, phytoestrogens, tannins, and protease inhibitors which interrupt with the mitotic activities of abnormal cells.
openaire   +1 more source