Results 211 to 220 of about 2,482,456 (261)
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Pharmacokinetic Optimisation of Anticancer Therapy
Clinical Pharmacokinetics, 1991It is obvious that there are great problems with pharmacokinetic individualization of anticancer therapy. The strong relationship between dose intensity (total dose/unit time) and response revealed in clinical trials with some tumours provides a strong support for studies seeking relationships between the individual plasma pharmacokinetic profile and ...
J, Liliemark, C, Peterson
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Tubulins - The Target for Anticancer Therapy
Current Topics in Medicinal Chemistry, 2015Tubulin has picked up great focus as a major target in drug discovery and consequently, tubulin inhibitors have pulling in a considerable attention as anticancer agents. Numerable naturally occurring agents have focused on tubulin system act as an imperative target of cancer chemotherapy.
N G, Vindya +3 more
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Sphingolipids in Anticancer Therapy
Current Medicinal Chemistry, 2006Sphingolipids constitute a broad class of compounds with many biological functions. The sphingolipid metabolites ceramide and sphingosine are potent apoptosis inducers and produce cell cycle arrest, whereas sphingosine-1-phosphate promotes cellular growth and differentiation.
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Telomerase: A Target for Anticancer Therapy
Annals of the New York Academy of Sciences, 1999Abstract: Telomerase is absent in most normal tissues, but is abnormally reactivated in all major cancer types. Telomerase enables tumor cells to maintain telomere length, allowing indefinite replicative capacity. Albeit not sufficient in itself to induce neoplasia, telomerase is believed to be necessary for cancer cells to grow without limit.
S P, Lichtsteiner +2 more
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Natural products in anticancer therapy
Current Opinion in Pharmacology, 2001Many pharmaceutical agents have been discovered by screening natural products from plants, animals, marine organisms and microorganisms. Vincristine, irinotecan, etoposide and paclitaxel are examples of plant-derived compounds that are being employed in cancer treatment, and dactinomycin, bleomycin and doxorubicin are anticancer agents derived from ...
A B, da Rocha +2 more
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AIEgens for synergistic anticancer therapy
Journal of Materials Chemistry B, 2023To improve the precision of cancer treatment, maximize therapeutic effects, and minimize mortality, AIEgen-based synergistic therapies combining imaging technologies, phototherapy, and other therapies will be introduced and perspected in this review.
Xinyan Lyu +7 more
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From the Sea to Anticancer Therapy
Current Medicinal Chemistry, 2011Discovery, isolation, characterisation and pre-clinical and clinical trials of plant- or animal-derived drugs displaying pharmacological activities continue to develop and enlarge. Cancer chemotherapy is one of the most promising areas for these drugs. Since a very long time, nature has been an attractive source of potential medicinal agents for human ...
P, Russo, C, Nastrucci, A, Cesario
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MDR Inhibitors for Anticancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2022Peter, Werner, Andreas, Hilgeroth
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Telomerase Inhibitors as Anticancer Therapy
Current Medicinal Chemistry-Anti-Cancer Agents, 2002Telomerase inhibitors have been touted as a novel cancer specific therapy, as most tumor cells have high expression of telomerase, whereas most normal somatic cells express low or undetectable levels of telomerase. Continued proliferation of tumor cells requires activation of telomerase to maintain chromosomal stability and extend life span, because ...
Masaharu, Akiyama +3 more
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Targeting SOX2 in anticancer therapy
Expert Opinion on Therapeutic Targets, 2018SOX2 is a transcription factor that is important in the development and maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer progression because it promotes the migration, invasion, and proliferation of cancer cells. SOX2 is also expressed in cancer stem cells and appears to be involved in the resistance toward anticancer ...
Laura, Hüser +4 more
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