Results 11 to 20 of about 83,224 (354)

Anticholinergic Drug Exposure Increases the Risk of Delirium in Older Patients Undergoing Elective Surgery

Frontiers in Medicine, 2022
IntroductionPostoperative delirium (POD) is a common and serious adverse event of surgery in older people. Because of its great impact on patients' safety and quality of life, identification of modifiable risk factors could be useful.
Matthias L. Herrmann, Matthias L. Herrmann, Cindy Boden, Christoph Maurer, Christoph Maurer, Felix Kentischer, Eva Mennig, Sören Wagner, Sören Wagner, Lars O. Conzelmann, Bernd R. Förstner, Michael A. Rapp, Christine A. F. von Arnim, Michael Denkinger, Michael Denkinger, Gerhard W. Eschweiler, Christine Thomas, Christine Thomas   +17 more
doaj   +2 more sources

Amitriptyline's anticholinergic adverse drug reactions-A systematic multiple-indication review and meta-analysis.

PLoS ONE, 2023
BackgroundHalf the US population uses drugs with anticholinergic properties. Their potential harms may outweigh their benefits. Amitriptyline is among the most frequently prescribed anticholinergic medicinal products, is used for multiple indications ...
Maria-Sophie Brueckle, Elizabeth T Thomas, Svenja Elisabeth Seide, Maximilian Pilz, Ana I Gonzalez-Gonzalez, Truc Sophia Dinh, Ferdinand M Gerlach, Sebastian Harder, Paul P Glasziou, Christiane Muth   +9 more
doaj   +2 more sources

Association between recently raised anticholinergic burden and risk of acute cardiovascular events: nationwide case-case-time-control study [PDF]

British medical journal, 2023
Objective To evaluate the association between recently raised anticholinergic burden and risk of acute cardiovascular events in older adults. Design Case-case-time-control study (ie, incorporating a case crossover design and a control crossover design ...
Wei-Ching Huang, Avery Shuei‐He Yang, Daniel Hsiang‐Te Tsai, Shih‐Chieh Shao, Swu‐Jane Lin, Edward Chia‐Cheng Lai   +5 more
openalex   +2 more sources

Effects of antipsychotic and anticholinergic medications on cognition in chronic patients with schizophrenia

BMC Psychiatry, 2023
Background Patients with psychosis frequently use a variety of psychotropic medicines, many of which have anticholinergic effects that can impair cognition.
C. Haddad, P. Salameh, H. Sacre, J. Clément, B. Calvet   +4 more
semanticscholar   +1 more source

Interventions for reducing anticholinergic medication burden in older adults—a systematic review and meta-analysis

Age and Ageing, 2023
Introduction Anticholinergic medications block the neurotransmitter acetylcholine in the brain and peripheral nervous system. Many medications have anticholinergic properties, and the cumulative effect of these medications is termed anticholinergic ...
Eve Braithwaite, O. Todd, Abigail Atkin, Rachel Hulatt, R. Tadrous, David P Alldred, M. Pirmohamed, Lauren Walker, Rebecca Lawton, A. Clegg   +9 more
semanticscholar   +1 more source

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults.

Cochrane Database of Systematic Reviews, 2023
BACKGROUND Around 16% of adults have symptoms of overactive bladder (OAB; urgency with frequency and/or urge incontinence), with prevalence increasing with age. Anticholinergic drugs are commonly used to treat this condition.
A. Stoniute, P. Madhuvrata, M. Still, Evelyn Barron-Millar, G. Nabi, M. I. Omar   +5 more
semanticscholar   +1 more source

The association between anticholinergic burden and mobility: a systematic review and meta-analyses

BMC Geriatrics, 2023
Background As people age, they accumulate several health conditions, requiring the use of multiple medications (polypharmacy) to treat them. One of the challenges with polypharmacy is the associated increase in anticholinergic exposure to older adults ...
G. O. Phutietsile, N. Fotaki, H. Jamieson, P. Nishtala   +3 more
semanticscholar   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

CRIDECO Anticholinergic Load Scale: An Updated Anticholinergic Burden Scale. Comparison with the ACB Scale in Spanish Individuals with Subjective Memory Complaints

Journal of Personalized Medicine, 2022
The increase in life expectancy has also been accompanied by an increase in the use of medication to treat chronic diseases. Polypharmacy is associated with medication-related problems such as the increase in the anticholinergic burden.
Hernán Ramos, Lucrecia Moreno, J. Pérez-Tur, C. Cháfer-Pericás, G. García-Lluch, J. Pardo   +5 more
semanticscholar   +1 more source

The anticholinergic burden: from research to practice

Australian Prescriber, 2022
SUMMARY Drugs with anticholinergic effects are known to cause adverse effects such as dry mouth, constipation and urinary retention. In older people drugs with anticholinergic effects may contribute to cognitive decline and a loss of functional capacity.
S. Hilmer, D. Gnjidic
semanticscholar   +1 more source