Results 111 to 120 of about 745,415 (340)
Neurobiological Underpinnings of Reward Anticipation and Outcome Evaluation in Gambling Disorder.
Frontiers in Behavioral Neuroscience, 2014 Gambling disorder is characterized by persistent and recurrent maladaptive gambling behavior, which leads to clinically significant impairment or distress. The disorder is associated with dysfunctions in the dopamine system.
Jakob eLinnet +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Are Self-Employed Really Happier than Employees?: An Approach Modelling Adaptation and Anticipation Effects to Self-Employment and General Job Changes [PDF]
Empirical analyses using cross-sectional and panel data found significantly higher levels of job satisfaction for self-employed than for employees.
Dominik Hanglberger, Joachim Merz
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The Future as Practice. A Framework to Understand Anticipation in Science and Technology
Tecnoscienza, 2016 The future has become a common theme in governance of contemporary societies, particularly in the context of technological development. It is presented as open and uncertain, which, either as an opportunity or as a threat, demands a sense of urgency ...
Carla Alvial-Palavicino
doaj +1 more source
Distributed Decision Making in Combined Vehicle Routing and Break Scheduling [PDF]
, 2009 The problem of combined vehicle routing and break scheduling comprises three subproblems: clustering of customer requests, routing of vehicles, and break scheduling.
Kok, Adrianus Leendert +3 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Anticipation and Risk – From the inverse problem to reverse computation [PDF]
, 2009 . Risk assessment is relevant only if it has predictive relevance. In this sense, the anticipatory perspective has yet to contribute to more adequate predictions.
Nadin, Mihai
core +1 more source
The politics of anticipation: the IPCC and the negative emissions technologies experience
Global Sustainability, 2018 Non-technical summary In the post-Paris political landscape, the relationship between science and politics is changing. We discuss what this means for the Intergovernmental Panel on Climate Change (IPCC), using recent controversies over negative ...
S. Beck, M. Mahony
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source