Results 121 to 130 of about 106,247 (265)

Commentary: Brain, Mind, World: Predictive Coding, Neo-Kantianism, and Transcendental Idealism

Frontiers in Psychology, 2017
Michał Piekarski
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Predictive Processing in Sport and Exercise Science: A Scoping Review and Theoretical Overview. [PDF]

Sports Med Open
Harris DJ, O'Malley CA, Beck D, Zahno S, Arthur T.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Commentary: Physical time within human time

Frontiers in Psychology, 2023
Mauro Dorato
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism. [PDF]

Nat Commun
Sambuco N, Lupo A, Hawkins PCT, Selvaggi P, Antonucci LA, Bertolino A, Blasi G, Di Palo P, Grassi L, Grasso D, Homan P, Leggio GM, Massari F, Monteleone AM, Osugo M, Passiatore R, Raio A, Rampino A, Banaschewski T, Barker GJ, Bokde ALW, Brühl R, Desrivières S, Flor H, Garavan H, Gowland P, Grigis A, Heinz A, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Smolka MN, Holz N, Vaidya N, Walter H, Whelan R, Schumann G, IMAGEN Consortium, Apulian Network on Risk for Psychosis, Howes OD, Mehta MA, Pergola G.   +44 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Anticipation-angle interaction identifies 45° unanticipated change of direction as a high-demand movement with altered ACL injury-related biomechanical characteristics. [PDF]

Front Bioeng Biotechnol
Mao C, Xie S, Wang Z, Yang X, Guan Z, Huang Y, Huang Y, Liu W.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source