Results 101 to 110 of about 322,983 (366)

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

Modern view on hemostasis system: cell theory

Медицинский совет, 2019
For many years, there has been no model capable of explaining the complex processes of interaction between various bloodclotting factors leading to a stop of bleeding.
I. V. Schastlivtsev, K. V. Lobastov, S. N. Tsaplin, D. S. Mkrtychev   +3 more
doaj   +1 more source

Clinical and laboratory practice for lupus anticoagulant testing : an International Society of Thrombosis and Haemostasis Scientific and Standardization Committee survey [PDF]

, 2019
Background Current guidelines have contributed to more uniformity in the performance and interpretation of lupus anticoagulant (LA) testing. However, points to reconsider include testing for LA in patients on anticoagulation, cut-off values, and ...
Cohen, Hannah, Devreese, Katrien, Mackie, Ian J., the International Society for Thrombosis and Haemostasis Scientific and Standardization Committee for Lupus Anticoagulant/Antiphospholipid Antibodies, [missing]   +3 more
core   +2 more sources

Single Test‐Based Diagnosis and Subtyping of Pulmonary Hypertension Caused by Fibrosing Mediastinitis Using Plasma Metabolic Analysis

Advanced Science, EarlyView.
Pulmonary hypertension caused by fibrosing mediastinitis has a five‐year survival rate of just 56%. Current diagnostic approaches are complex for patients with mobility limitations and can lead to misdiagnoses due to their nonspecific clinical features.
Yating Zhao, Chunmeng Ding, Hongling Su, Aqian Wang, Aiping Tang, Hongfan Zhao, Ya Ma, Min Zhang, Wanshan Liu, Ruimin Wang, Ziyue Zhang, Shouzhi Yang, Dingyitai Liang, Yida Huang, Kun Qian, Lin Huang, Qihua Fu, Yunshan Cao   +17 more
wiley   +1 more source

Automated Identification of Drug-Drug Interactions in Pediatric Congestive Heart Failure Patients [PDF]

arXiv, 2017
Congestive Heart Failure, or CHF, is a serious medical condition that can result in fluid buildup in the body as a result of a weak heart. When the heart can't pump enough blood to efficiently deliver nutrients and oxygen to the body, kidney function may be impaired, resulting in fluid retention.
arxiv  

Cerebrovascular complications and infective endocarditis. impact of available evidence on clinical outcome [PDF]

, 2018
Infective endocarditis (IE) is a life-threatening disease. Its epidemiological profile has substantially changed in recent years although 1-year mortality is still high.
De Bellis, Antonio, D’Abramo, Mizar, Frati, Giacomo, Greco, Ernesto, Iaccarino, Alessandra, Mestres, Carlos-A., Saade, Wael, Schirone, Leonardo, Sciarretta, Sebastiano   +8 more
core   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Successful treatment of massive thrombosis of the vena cava inferior with nephrоtic syndrome and chronic bilateral pulmonary artery thromboembolism in a patient with genetic thrombophilia

Терапевтический архив, 2012
A case is reported of a 23-year-old male patient who developed, after severe blunt injury of the lumbar region, massive thrombosis of the vena cava inferior (VCI), both renal veins, bilateral pulmonary artery thromboembolism (PATE), nephrоtic syndrome ...
Ol'ga Vladimirovna Blagova, S L Dzemeshkevich, N L Kozlovskaya, A V Nedostup, N D Sarkisova, Yu V Frolova, V V Raskin, A S Dzemeshkevich, S A Abugov, O G Skipenko, E M Shilov, V P Sedov, N V Gagarina, V E Sinitsyn, E A Mershina, E Yu Volkova, O V Blagova, S L Dzemeshkevich, N L Kozlovskaya, A V Nedostup, N D Sarkisova, Yu V Frolova, V V Raskin, A S Dzemeshkevich, S A Abugov, O G Skipenko, E M Shilov, V P Sedov, N V Gagarina, V E Sinitsyn, E A Mershina, E Yu Volkova   +31 more
doaj  

Patient-Specific Effects of Medication Using Latent Force Models with Gaussian Processes [PDF]

arXiv, 2019
Multi-output Gaussian processes (GPs) are a flexible Bayesian nonparametric framework that has proven useful in jointly modeling the physiological states of patients in medical time series data. However, capturing the short-term effects of drugs and therapeutic interventions on patient physiological state remains challenging.
arxiv  

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source