Results 1 to 10 of about 380,856 (149)

The hidden threat: understanding anti-PF4 disorders without proximate heparin exposure [PDF]

Frontiers in Immunology
Heparin-induced thrombocytopenia (HIT) is now recognized as one subset of a broader group of disorders: anti-platelet factor 4 (anti-PF4) disorders.
Zhiyan Liu, Yan Li, Liang Ma, Xin Wang, Yimin Cui   +4 more
doaj   +2 more sources

Electrospun Heparin-Loaded PCL Nanofiber Sutures with Sustained Release for Antithrombotic Applications [PDF]

Pharmaceuticals
Background/Objectives: Conventional surgical sutures can promote local coagulation after implantation, potentially compromising vascular patency. Heparin is an effective anticoagulant, but systemic administration may cause bleeding and thrombocytopenia ...
Yixiang Pan, Yiting Zhu, Wenjie Chen, Jie Xu, Jinhang Ma, Odinaka Cassandra Ezekiel, Hailv Ye, Jiang Wu   +7 more
doaj   +2 more sources

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation [PDF]

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) mediate cell‐to‐cell communication in development, health and disease. Heparin is a common component in human induced pluripotent stem cell (hiPSC) media but its impact on hiPSC‐EVs beyond stabilizing growth factors is ...
André Cronemberger Andrade, Rodolphe Poupardin, Martin Wolf, Liliia Paniushkina, Karim Selmi, Deepika Kundully Suresh, Nicole Maeding, Heide‐Marie Binder, Janine Zwicklhuber, Sarah Hochmann, André Görgens, Samir El Andaloussi, Katharina Schallmoser, Dirk Strunk   +13 more
doaj   +2 more sources

The anti-cancer properties of heparin and its derivatives: a review and prospect

Cell Adhesion and Migration, 2020
Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival.
Jin-Hai Tang, Ming-Xing Liang, Zhi-Xiang Mao   +2 more
exaly   +2 more sources

Biomedical applications of engineered heparin-based materials

Bioactive Materials
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in ...
Haroon Khan, Tarun Agarwal, Danial Khorsandi   +2 more
exaly   +3 more sources

Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

Thrombosis Journal, 2021
Background This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain coronavirus vaccines.
Payel Datta, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt   +3 more
doaj   +1 more source

Influence of different levels of heparin and antithrombin Ⅲ on human coagulation factor Ⅸ activity

Zhongguo shuxue zazhi, 2022
Objective To study the effect of different concentrations of heparin, ATⅢ or a mixture of heparin and antithrombin Ⅲ (ATⅢ) (1∶1)on the activity of human coagulation factor Ⅸ (FⅨ).
Changyong JIAN, Miaomiao DOU, chen CHEN, An ZHOU, Chao GAO, Cuiping ZHANG   +5 more
doaj   +1 more source

Quantitative Analysis of Impurities in Unfractionated Heparin of Bovine Origin

Frontiers in Medicine, 2020
The USP heparin sodium monograph lists impurities with specifications developed for porcine derived products. Most of these impurities are of biological origin and are present in porcine intestinal mucosa, the tissue source used in the production of ...
Wesley E. Workman, Kevin L. Carrick
doaj   +1 more source

Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Heliyon, 2020
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion ...
Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi   +8 more
doaj   +1 more source

Heparin-induced thrombocytopenia occurring early after living donor liver transplantation: a case report

Emergency and Critical Care Medicine, 2023
. Background. Thrombocytopenia commonly occurs early after liver transplantation. Heparin, usually administered as anticoagulant therapy for thrombosis, a common complication after liver transplantation, may cause heparin-induced thrombocytopenia ...
Naoya Iwasaki, Motohiro Sekino, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Yusuke Kasai, Miki Suzumura, Hiroshi Araki, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Susumu Eguchi, Tetsuya Hara   +13 more
doaj   +1 more source