Results 21 to 30 of about 507,262 (350)

Pharmacological and clinical application of heparin progress: An essential drug for modern medicine.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is still used in a variety of clinical indications. Since it was discovered in 1916, after more than a century of repeated exploration, heparin has not been replaced ...
Min Qiu, Shengjie Huang, Chuan-hong Luo, Zhenfeng Wu, Bin Liang, Hao-zhou Huang, Zhi-min Ci, Ding-kun Zhang, Li Han, Junzhi Lin   +9 more
semanticscholar   +1 more source

Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Heliyon, 2020
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion ...
Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi   +8 more
doaj   +1 more source

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

Thrombosis and Haemostasis, 2020
The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of ...
Courtney J. Mycroft-West, Dunhao Su, I. Pagani, T. Rudd, S. Elli, Neha S. Gandhi, S. Guimond, G. Miller, Maria C. Z. Meneghetti, H. Nader, Yong Li, Quentin M. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, N. Forsyth, V. Ferro, J. Turnbull, M. Guerrini, D. Fernig, E. Vicenzi, E. Yates, M. Lima, M. Skidmore   +24 more
semanticscholar   +1 more source

Heparin-Assisted Amyloidogenesis Uncovered through Molecular Dynamics Simulations [PDF]

, 2022
Glycosaminoglycans (GAGs), in particular, heparan sulfate and heparin, are found colocalized with Aβ amyloid. They have been shown to enhance fibril formation, suggesting a possible pathological connection.
Alamzeb Khan (12441416), Jamshed Anwar (1988818), Abdul Wadood, Beenish Khurshid, Ashfaq Ur Rehman, Abdul Wadood (390961), Jamshed Anwar, Ray Luo (141237), Alamzeb Khan, Beenish Khurshid (12441413), Ray Luo, Ashfaq Ur Rehman (6117374)   +11 more
core   +1 more source

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

bioRxiv, 2020
Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to ...
Courtney J. Mycroft-West, Dunhao Su, S. Elli, Yong Li, S. Guimond, G. Miller, J. Turnbull, E. Yates, M. Guerrini, D. Fernig, M. Lima, M. Skidmore   +11 more
semanticscholar   +1 more source

Heparin modification of a biomimetic bone matrix modulates osteogenic and angiogenic cell response in vitro [PDF]

European Cells & Materials, 2017
In this study, the effect of heparin-modified collagen type I/hydroxyapatite (HA) nanocomposites on key processes of bone regeneration – osteogenesis and angiogenesis – was characterised in vitro.
M Quade, S Knaack, D Weber, U König, B Paul, P Simon, A Rösen-Wolff, R Schwartz-Albiez, M Gelinsky, A Lode   +9 more
doaj   +1 more source

Heparin as a therapy for COVID-19: current evidence and future possibilities

American Journal of Physiology - Lung cellular and Molecular Physiology, 2020
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every country in the world.
J. Hippensteel, W. Lariviere, James F. Colbert, Christophe J. Langouët-Astrié, E. Schmidt   +4 more
semanticscholar   +1 more source

Heparin release kinetics in blood gas syringes [PDF]

, 2008
Background: In view of the urgency of results quality and operational availability of point of care analyzers is of high importance in ICUs and operational theatres. Methods: We investigated the influence of time on release and total amount of Heparin in
Bechmann, Volker, Gruber, Michael, Spaeth, Ruth   +2 more
core   +1 more source

Heparin [PDF]

Reactions Weekly, 2021
  +16 more sources

Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies

Blood Advances, 2017
: Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery.
Grace M. Lee, Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M. Arepally   +6 more
doaj   +1 more source