Results 131 to 140 of about 467,565 (384)

Sex-related differences in risk factors, type of treatment received and outcomes in patients with atrial fibrillation and acute stroke: Results from the RAF-study (Early Recurrence and Cerebral Bleeding in Patients with Acute Ischemic Stroke and Atrial Fibrillation) [PDF]

, 2016
Introduction: Atrial fibrillation is an independent risk factor of thromboembolism. Women with atrial fibrillation are at a higher overall risk for stroke compared to men with atrial fibrillation. The aim of this study was to evaluate for sex differences
Abdul-Rahim, Azmil, Acciarresi, Monica, Ageno, Walter, Agnelli, Giancarlo, Akhtar, Naveed, Alberti, Andrea, Antonenko, Kateryna, Baldi, Antonio, Barlinn, Kristian, Baronello, Mario M., Becattini, Cecilia, Bodechtel, Ulf, Bono, Giorgio, Bovi, Paolo, Carletti, Monica, Carolei, Antonio, Caso, Valeria, Chiti, Alberto, Consoli, Domenico, Cordier, Maria, Corea, Francesco, Csiba, Laszló, De Lodovici, Maria Luisa, Del Sette, Massimo, Deleu, Dirk, Denti, Licia, Doronin, Boris, D’Amore, Cataldo, D’Anna, Antonio, Falocci, Nicola, Galati, Franco, Gerber, Johannes, Gialdini, Gino, Guideri, Francesca, Ibrahim, Faisal, Imberti, Davide, Kepplinger, Jessica, Lees, Kennedy R., Lorenzini, Gianni, Marcheselli, Simona, Martini, Giuseppe, Masotti, Luca, Melikyan, Gayane, Michel, Patrik, Monaco, Serena, Mosconi, Maria G., Orlandi, Giovanni, Paciaroni, Maurizio, Padovani, Alessandro, Pallesen, Lars-Peder, Papageorgiou, Sokratis G., Pezzini, Alessandro, Pieroni, Alessio, Poli, Loris, Putaala, Jukka, Remillard, Suzette, Rigatelli, Alberto, Rueckert, Christina, Sacco, Simona, Scoditti, Umberto, Sohn, Sung-Il, Szabó6, Lilla, Tassi, Rossana, Tassinari, Tiziana, Tatlisumak, Turgut, Tiseo, Cindy, Toni, Danilo, Tsivgoulis, Georgios, Vadik, Kostantinos, Vanacker, Peter, Venti, Michele, Volodina, Vera, Zabzuni, Dorjan   +72 more
core   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

Major Bleeding Complications and Persistence With Oral Anticoagulation in Non‐Valvular Atrial Fibrillation: Contemporary Findings in Real‐Life Danish Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe nonvitamin K antagonist oral anticoagulants have recently become available as an alternative to warfarin as stroke prophylaxis in atrial fibrillation, but data on real‐life patient experience, including bleeding risk, are lacking.
Morten Lamberts, Laila Staerk, Jonas Bjerring Olesen, Emil Loldrup Fosbøl, Morten Lock Hansen, Louise Harboe, Cinira Lefevre, David Evans, Gunnar Hilmar Gislason   +8 more
doaj   +1 more source

Blood loss in primary total knee arthroplasty-body temperature is not a significant risk factor-a prospective, consecutive, observational cohort study [PDF]

, 2015
BACKGROUND: Hypothermia related to anaesthesia and operating theatre environment is associated with increased blood loss in a number of surgical disciplines, including total hip arthroplasty.
Beller, Elaine, Dan, Michael, Jones, Peter, Liu, David, Martos, Sara Martinez, Randle, Ray   +5 more
core   +2 more sources

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Dicumarol [PDF]

, 1945
Thesis (M.D.)--Boston ...
Steel, Robert MacDonald
core  

WSGC@FA@PEG/PEI‐SPIONs Mitigate Chemoresistance in Gastric Adenocarcinoma by Modulating the Notch Signaling Pathway and Mitophagy

Advanced Science, EarlyView.
WSGC peptide reverses drug resistance in GA by modulating the Notch signaling pathway and mitophagy at the molecular level. Abstract This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI‐SPIONs)—a 40‐amino acid polypeptide derived from apoC‐III ...
Dongjian Song, Qiuliang Liu, Zechen Yan, Qi Wang, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang, Da Zhang   +10 more
wiley   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

London SynEx Demonstrator Site: Impact Assessment Report [PDF]

, 2000
The key ingredients of the SynEx-UCL software components are: 1. A comprehensive and federated electronic healthcare record that can be used to reference or to store all of the necessary healthcare information acquired from a diverse range of clinical
Austin, A., Ingram, D., Kalra, D., Lloyd, D., O’Connor, A., Patterson, D.   +5 more
core  

Clinical Evaluation of Dicumarinyl Derivatives with a Metabolic Study of the Radioactively Labeled Anticoagulants in Animals [PDF]

, 1951
ERIC P. HAUSNER, CHARLES L. SHAFER, Marion Corson, O.Douglas Johnson, T. T. Trujillo, Wright H. Langham   +5 more
openalex   +1 more source