Results 121 to 130 of about 4,582,351 (335)

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He   +11 more
wiley   +1 more source

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

open access: yesAdvanced Science, EarlyView.
The nano‐electro‐platform achieves non‐destructive evolutionary screening and electro‐remodeling of tumor cells to generate extracellular vesicles with enhanced tumor‐targeting and therapeutic functions. These extracellular vesicles demonstrate remarkable efficacy in activating both macrophages and T cells, thereby orchestrating a potent immune ...
Feng Liu   +20 more
wiley   +1 more source

MOF Coating Enhances the Ion Tolerance of Micromotors

open access: yesAngewandte Chemie, EarlyView.
This work reported a novel method to significantly enhance the ion tolerance of EMNMs using a MOF coating via controllable heteroepitaxial growth, enabling effective motion in high‐salt environments and propulsion through biological tissues under 980 nm NIR light, with potential applications in targeted drug delivery.
Leyan Ou   +10 more
wiley   +2 more sources

Knowledge, Attitude, and Practice on Atrial Fibrillation and Atrial Fibrillation Screening in High‐Risk Population: A Cross‐Sectional Study

open access: yesAGING MEDICINE, EarlyView.
Distribution of KAP scores for participants ≤ 65 versus > 65 years. ABSTRACT Objectives Atrial fibrillation (AF) is a common clinical arrhythmia. Failure to identify AF leaves patients at a considerably higher risk of disability and death, making its early screening and prevention extremely important. This study aimed to investigate knowledge, attitude,
Zhong Yi   +12 more
wiley   +1 more source

Problems Associated with Long-Term Anticoagulant Therapy [PDF]

open access: bronze, 1962
J.W. Pollard   +3 more
openalex   +1 more source

Influence of Facility Size on Perioperative Outcomes in Minimally Invasive Esophagectomy for 14 152 Patients With Esophageal Cancer Based on the Japanese National Clinical Database: A Multicenter Cohort Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This multicenter study investigated 14 152 minimally invasive esophagectomies (MIEs) using data from the Japanese National Clinical Database and showed a significantly lower operative mortality rate in high‐volume centers than in low‐volume centers. However, no differences in morbidity rates were found between facility sizes.
Taro Oshikiri   +4 more
wiley   +1 more source

Two‐Stage Treatment for Adult Large Patent Ductus Venosus

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This is the first report of a two‐stage treatment for an adult large PDV involving the first stage surgical angioplasty of the large Arantius' duct and second stage embolization of the formed small Arantius' duct. The two‐stage approach could avoid embolic material migration into the systemic circulation or acute portal hypertension associated with the
Shohei Kudo   +4 more
wiley   +1 more source

Risk Evaluation of the NCD Risk Calculator for Open Pancreaticoduodenectomy in Elderly Patients: A Validation Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study investigated the utility of the Japanese NCD risk calculator for preoperative assessment in elderly patients undergoing pancreaticoduodenectomy (PD), using a validation study design. In the training cohort, two preoperative factors—the predicted incidence of postoperative ADL decline ≥ 44.8% and Clavien–Dindo grade IV or higher complications
Nana Kimura   +9 more
wiley   +1 more source

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