Results 251 to 260 of about 4,600,401 (406)

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler   +11 more
wiley   +1 more source

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman   +14 more
wiley   +1 more source

Mechanochemical Approach for Metal‐Free Regioselective C5‐Sulfenylation of Imidazo[2,1‐b]thiazoles

open access: yesChemSusChem, Accepted Article.
The development of sustainable and selective methodologies for heterocyclic functionalization remains a key challenge in organic synthesis. In this study, we report a novel, metal‐free bis(trifluoroacetoxy)iodo]benzene (PIFA)‐mediated strategy for the regioselective C5‐sulfenylation of imidazo[2,1‐b]thiazoles using aryl methyl sulfides under ...
Xinya Liu   +6 more
wiley   +1 more source

Evaluation of Dose-Reduced Direct Oral Anticoagulant Therapy.

open access: yesAmerican Journal of Medicine, 2016
M. Barra   +5 more
semanticscholar   +1 more source

Methodology of high‐dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Characterization of the tumor immune microenvironment (TIME) of pituitary neuroendocrine tumors (PitNETs) is crucial for understanding the behavior of different types of PitNETs and identification of possible causes of their aggressiveness, rapid growth, and resistance to therapy.
Marina Yu Loguinova   +13 more
wiley   +1 more source

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