Results 131 to 140 of about 355,585 (385)

Drug-drug interactions in an era of multiple anticoagulants: a focus on clinically relevant drug interactions.

Blood, 2018
Oral anticoagulants are commonly prescribed but high risk to cause adverse events. Skilled drug interaction management is essential to ensure safe and effective use of these therapies.
S. Vazquez
semanticscholar   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma. [PDF]

, 2018
It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein
Burra, P, Campello, E, Russo, Fp., Simioni, P, Spiezia, L, Zanetto, A   +5 more
core   +1 more source

Anticoagulation in the young [PDF]

Heart, 2004
Congenital heart disease, with a wide spectrum of severity, affects approximately 1% of all live births. The majority of congenital cardiac structural abnormalities occur in otherwise healthy children and total correction of the cardiac lesion usually results in a normal productive lifespan.
openaire   +2 more sources

Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 Pathway

Advanced Science, EarlyView.
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang, Yunda Fang, Yuheng Lian, Ziyang Kong, Jia Miao, Yanqi Chen, Wen Li, Feiyan Chen, Bin Zhang, Yao Chen, Yaoyao Bian   +10 more
wiley   +1 more source

Spontaneous suprachoroidal hemorrhage due to the excessive anticoagulation therapy. Case report

Oftalʹmologiâ, 2014
Anticoagulant therapy is often used to treat various conditions. This often can deviate in the hemostatic system in the direction of hypocoagulation and increase risk of hemostatic complications. The article describes suprachoroidal hemorrhage in the eye
A. Stepanov,, N. Jiraskova, P. Rozsival, E. Rencova, J. Lackovic   +4 more
doaj   +1 more source

Patient safety: are we maximizing the potential of the pharmacist's role? [Editorial] [PDF]

, 2009
Original article can be found at: http://www.medicinescomplete.com/journals/ijpp/current/ Copyright Pharmaceutical Press.Peer ...
Dhillon, S.
core   +1 more source

Predicting major bleeding among hospitalized patients using oral anticoagulants for atrial fibrillation after discharge

, 2021
Jakub Z. Qazi, Mireille E. Schnitzer, Robert Côté, Marie-Josée Martel, Marc Dorais, Sylvie Perreault   +5 more
openalex   +2 more sources

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source