Results 131 to 140 of about 227,135 (339)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Evolution of Left Atrial Thrombus with Anticoagulant Therapy-Follow-up by Transesophageal Echocardiography [PDF]

, 1995
Cheol Ho Kim, Seung Woo Park, Joo Hee Zo, Byung‐Hee Oh, Myoung Mook Lee, Jung Don Seo, Young Woo Lee   +6 more
openalex   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Extracranial Carotid and Vertebral Artery Dissection

Український журнал серцево-судинної хірургії
Cervical artery dissection (CAD) is a rare vascular pathology that causes stroke in 2.0% of cases and is the most common cause of ischemic stroke among young patients.
Ihor I. Kobza, Yuliia S. Mota
doaj   +1 more source

1354The effect of non-recommended dosing of non-vitamin K antagonist oral anticoagulants (NOACs) on 1-year mortality in patients with newly diagnosed AF? Results from the GARFIELD-AF registry [PDF]

, 2018
A. John Camm, Frank Cools, Saverio Virdone, Jean‐Pierre Bassand, David Fitzmaurice, Keith A.A. Fox, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, LG Mantovani, Karen S. Pieper, Alexander G.G. Turpie, Freek W.A. Verheugt, A. K. Kakkar, GARFIELD-AF Investigators   +14 more
openalex   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

Advanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi, Renliang Zhao, Jia Wang, Zhenchen Xiong, Xiangtian Deng, Cheng Zheng, Wenzhi Zhang   +6 more
wiley   +1 more source

Tratamiento quirúrgico de la enfermedad valvular cardiaca de predominio izquierdo, en un hospital de referencia nacional de Lima, Perú

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Describir las características preoperatorias, intraoperatorias y posoperatorias de los pacientes con enfermedad valvular cardiaca de predominio izquierdo (EVCPI) tratados en un servicio de cirugía de tórax y cardiovascular de un hospital de ...
Julio C. Vasquez, Ciro A. Barrantes, Julio E. Peralta, Luis E. Rojas   +3 more
doaj  

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Preemptive anticoagulation during antenatal pulmonary embolism diagnostics in a community setting: retrospective cohort study

Research and Practice in Thrombosis and Haemostasis
Background: Society recommendations for preemptive (or empiric) anticoagulation during antenatal pulmonary embolism (PE) diagnostics rely on expert opinion, which varies widely across guidelines.
Aidan R. Campbell, Cole J. Florio, Grace V. Heringer, Sara T. Woldemariam, Scott D. Casey, William B. Stubblefield, Lauren M. Westafer, Edward Qiao, Cydney E. Middleton, Lara Zekar, Nachiketa Gupta, Madeline J. Somers, Mary E. Reed, Nareg H. Roubinian, Ashok P. Pai, Jeffrey D. Sperling, David R. Vinson   +16 more
doaj   +1 more source