Results 131 to 140 of about 230,224 (366)

Admissibility in Partial Conjunction Testing [PDF]

arXiv, 2015
Meta-analysis combines results from multiple studies aiming to increase power in finding their common effect. It would typically reject the null hypothesis of no effect if any one of the studies shows strong significance. The partial conjunction null hypothesis is rejected only when at least $r$ of $n$ component hypotheses are non-null with $r = 1 ...
arxiv  

A Six‐Step Approach for Optimizing Ultrasound‐Guided Femoral Artery Access

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Femoral arterial access is fundamental to interventional cardiology, especially for complex procedures that require large‐bore devices. However, vascular complications arising from suboptimal puncture techniques highlight the need for meticulous practice.
Fernando Luiz de Melo Bernardi, Guilherme Luiz de Melo Bernardi, Júlio Roberto Barbiero, Adalberto Gloeckner de Meira, Luiz Felipe Monsanto Fernandes Alves, Dinaldo Cavalcanti de Oliveira, Estevão Carvalho de Campos Martins   +6 more
wiley   +1 more source

Second-Order Inference for the Mean of a Variable Missing at Random [PDF]

arXiv, 2015
We present a second-order estimator of the mean of a variable subject to missingness, under the missing at random assumption. The estimator improves upon existing methods by using an approximate second-order expansion of the parameter functional, in addition to the first-order expansion employed by standard doubly robust methods. This results in weaker
arxiv  

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Direct quantification of brown algae-derived fucoidans in human plasma by a fluorescent probe assay [PDF]

arXiv, 2016
Fucoidan is a generic term for a class of fucose rich, structurally diverse sulfated polysaccharides that are found in brown algae and other marine organisms. Depending on the species from which the fucoidan is extracted, a wide variety of biological activities including antitumor, antiinflammatory, immune-modulating, antiviral, antibacterial and pro ...
arxiv  

Prevention of venous thromboembolism after hip and knee replacement among older adults [PDF]

, 2017
BACKGROUND: Venous thromboembolism (VTE) after total hip and knee replacement is a major patient safety threat, and pharmacologic prophylaxis is generally recommended. However, clinicians disagree on the optimal prophylaxis agent.
Ko, Darae
core  

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

ChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

A Novel Two-stage Deming Regression Framework with Applications to Association Analysis between Clinical Risks [PDF]

arXiv
In healthcare, clinical risks are crucial for treatment decisions, yet the analysis of their associations is often overlooked. This gap is particularly significant when balancing risks that are weighed against each other, as in the case of atrial fibrillation (AF) patients facing stroke and bleeding risks with anticoagulant medication.
arxiv  

Quantification of heparin in complex matrices (including urine) using a mix-and-read fluorescence assay [PDF]

arXiv, 2016
Heparin is an important anticoagulant drug, about one billion doses are produced annually. It is a polydisperse sulfated polysaccharide, and the inherent heterogeneity makes the analysis of heparin difficult. The global crisis resulting from adulterated heparin in 2008 has drawn renewed attention to the challenges that are associated with the quality ...
arxiv  

MONITORING ANTICOAGULATION AND REVERSAL - EFFECT ON BLOOD LOSS [PDF]

, 1979
David R. Jobes, Alan Jay Schwartz, Norig Ellison, R. Andrews, R Ruffini, J. Ruffini   +5 more
openalex   +1 more source