Results 101 to 110 of about 105,937 (401)

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård   +7 more
wiley   +1 more source

Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]

open access: yes, 2008
Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A.   +3 more
core   +2 more sources

Implementing physician‐led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen   +2 more
wiley   +1 more source

Challenges in the Treatment of Epilepsy [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 2012
Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled ...
H.A Ebrahimi
doaj  

Simultaneous determination of three anticonvulsants using hydrophilic interaction LC-MS.

open access: yesJournal of Separation Science, 2009
A specific and automated method was developed to quantify the anticonvulsants gabapentin, pregabalin and vigabatrin simultaneously in human serum. Samples were prepared with a protein precipitation. The hydrophilic interaction chromatography (HILIC) with
R. Oertel   +3 more
semanticscholar   +1 more source

What is the best treatment for diabetic neuropathy? [PDF]

open access: yes, 2004
Tricyclic antidepressants, anticonvulsants, and capsaicin reduce the pain of diabetic neuropathy; limited data suggests that lidocaine patches may also be efficacious.
Collins, Linda J., Newton, Warren P.
core  

Management of Widespread Pain and Fibromyalgia [PDF]

open access: yes, 2016
Peer reviewedPublisher ...
Basu, Neil   +2 more
core   +2 more sources

EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported to the European ADR database, EudraVigilance. The research sought to understand the frequency, seriousness and nature of these ADRs to assess potential risks associated with maternal medication use ...
Ida M. Heerfordt   +7 more
wiley   +1 more source

Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase‐3 and caspase‐9 during apoptosis

open access: yesFood Science &Nutrition, Volume 11, Issue 1, Page 249-260, January 2023., 2023
This study indicated, for the first time, that (±) linalool and its enantiomer, (R)‐(‐) linalool protected PC12 cells against injury induced by oxygen and glucose deprivation/reoxygenation (OGD/R) via the mitigation of oxidative stress and the downregulation of Bax/Bcl‐2, caspase‐3 and caspase‐9, resulting in decreased apoptotic cell death.
Azar Hosseini   +5 more
wiley   +1 more source

Immediate Therapeutic Response to Vigabatrin in Lissencephaly‐Related Epileptic Spasms due to TUBA1A R402H Variant

open access: yes
American Journal of Medical Genetics Part A, EarlyView.
Toru Nagata   +6 more
wiley   +1 more source

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