Results 51 to 60 of about 70,021 (342)
Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy
Advanced Science, EarlyView.This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan +4 more
wiley +1 more source
Acne and anticonvulsants. [PDF]
BMJ, 1983 The severity of acne and rate of excretion of sebum were assessed in 243 patients with epilepsy taking various anticonvulsants who were in hospital long term and in matched controls derived from a normal population of 2176 people. Neither the prevalence of acne nor the sebum excretion rate significantly increased in the patients compared with the ...
W. J. Cunliffe +2 more
openaire +3 more sources
Management of Widespread Pain and Fibromyalgia [PDF]
, 2016 Peer reviewedPublisher ...
Basu, Neil +2 more
core +2 more sources
Advanced Science, EarlyView.Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen +16 more
wiley +1 more source
Throat and rectal swabs may have an important role in MRSA screening of critically ill patients.
, 2008 OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) is a major problem in intensive care units (ICU). International guidelines recommend screening patients for MRSA on admission, although consensus on sites required for optimum detection has ...
Batra, Rahul +3 more
core +1 more source
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
Advanced Science, EarlyView.By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao +14 more
wiley +1 more source
Preventive treatment response associated with migraine aura subtypes in a Thai population
Frontiers in Human Neuroscience, 2023 IntroductionSome studies indicate a different response to treatment between migraine patients with and without aura.ObjectivesTo determine whether aura, or simple or complex aura subtypes, are clinical markers predicting response to preventive treatment ...
Thanin Asawavichienjinda +1 more
doaj +1 more source
American Journal of Industrial Medicine, EarlyView.ABSTRACT Rationale Industry guidelines recommend work‐rest allocations to limit increases in core temperature (Tcore; > 38.0°C or > Δ1.0°C above resting) during work in the heat. However, the initial duration of permissible work before implementing these allocations is not specified (initial stay time [IST]) and individual factors such as sex and age ...
Fergus K. O'Connor +11 more
wiley +1 more source
An update on available pain medications
South African Family Practice, 2018 Pain is a complex interaction of sensory, emotional and behavioural factors. Chronic pain is among the most common reasons for seeking medical attention.
Elzbieta Osuch, Andre Marais
doaj +1 more source