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Pharmacogenetics of Antidepressants
1989The metabolism of tricyclic antidepressants is catalysed by the cytochrome P- 450 family of isozymes. The tertiary amines amitriptyline, imipramine and chlorimipramine are all demethylated to active secondary amines. Desmethylimipramine and nortriptyline, on the other hand, are hydroxylated in aromatic and benzylic positions, respectively.
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Antidepressants and the Elderly
Journal of the American Geriatrics Society, 1986The pharmacologic treatment of depression in the elderly is often complicated by cardiovascular disease and other medical illnesses. Both the tricyclic antidepressants and the monoamine oxidase (MAO) inhibitors have adverse effects that are potentially dangerous in this age group.
Peabody, CA +2 more
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[Discontinuation of antidepressant serotonergic antidepressant].
Ugeskrift for laeger, 2010A middle-aged female patient who had been automedicating with two different selective serotonin reuptake inhibitors and a selective serotonin-noradrenalin-reuptake inhibitor (SNRI) was non-intentionally exposed to an abrupt dose reduction upon admittance which caused her to develop the SNRI discontinuation syndrome (DS) ten days later.
Christen Lykkegaard, Andersen +1 more
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Annual Review of Pharmacology and Toxicology, 1993
L E, Hollister, J L, Claghorn
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L E, Hollister, J L, Claghorn
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