Clinical Pharmacology &Therapeutics, EarlyView.Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre +9 more
wiley +1 more source
Interactions between Sympathomimetic Amines and Antidepressant Agents in Man [PDF]
, 1973 A J Boakes +5 more
openalex +1 more source
Down-regulation of serotonergic genes expression in the raphe nuclei of midbrain under chronic social defeat stress in male mice [PDF]
, 2011 Background: There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety.
Maxim L. Filipenko +3 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi‐institutional prospective study [NCT03225820] in which African American inpatients were genotyped and ...
Zhong Huang +17 more
wiley +1 more source
Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain [PDF]
, 1970 Johan Schubert +2 more
openalex +1 more source
Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization
Clinical Pharmacology &Therapeutics, EarlyView.Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su +6 more
wiley +1 more source
EFFECTS OF MIANSERIN, A NEW ANTIDEPRESSANT, ON THE in vitro AND in vivo UPTAKE OF MONOAMINES [PDF]
, 1977 I Goodlet +2 more
openalex +1 more source
Medicaid Policy Changes in Mental Health Care and Their Effect on Mental Health Outcomes [PDF]
In recent years, Medicaid has experienced a dramatic increase in spending on prescription drugs in general and psychotropic medications in particular.
Alison Cuellar, Sara Markowitz
core
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety.
Alex J. Coulter +4 more
wiley +1 more source
OLFACTORY BULB ABLATION IN THE RAT: BEHAVIOURAL CHANGES AND THEIR REVERSAL BY ANTIDEPRESSANT DRUGS [PDF]
, 1977 Henk van Riezen, H. Schmieden, A. Wren
openalex +1 more source