Results 31 to 40 of about 391,178 (335)

Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior

Translational Psychiatry, 2019
Accumulating evidence demonstrates that the gut microbiota affects brain function and behavior, including depressive behavior. Antidepressants are the main drugs used for treatment of depression. We hypothesized that antidepressant treatment could modify
I. Lukic, Dmitriy Getselter, O. Ziv, O. Oron, E. Reuveni, O. Koren, E. Elliott   +6 more
semanticscholar   +1 more source

Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish

Cells, 2021
Antidepressants are well-known drugs to treat depression and major depressive disorder for humans. However, the misuse and abuse of antidepressants keep increasing with several side effects reported.
Michael Edbert Suryanto, Gilbert Audira, Boontida Uapipatanakul, Akhlaq Hussain, Ferry Saputra, Petrus Siregar, Kelvin H.-C. Chen, Chung-Der Hsiao   +7 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Antidepressants vs. Placebo for the Treatment of Functional Gastrointestinal Disorders in Adults: A Systematic Review and Meta-Analysis

Frontiers in Psychiatry, 2018
Objective: To integrate high-quality evidence of the efficacy of antidepressants across different subtypes of functional gastrointestinal disorders (FGIDs).Methods: The Medline, PsycINFO, EMBASE, the Cochrane Library, and Chinese local database were ...
Nana Xiong, Yanping Duan, Jing Wei, Ricarda Mewes, Rainer Leonhart   +4 more
doaj   +1 more source

Understanding Side Effects of Antidepressants: Large-scale Longitudinal Study on Social Media Data

JMIR Mental Health, 2021
BackgroundAntidepressants are known to show heterogeneous effects across individuals and conditions, posing challenges to understanding their efficacy in mental health treatment.
Saha, Koustuv, Torous, John, Kiciman, Emre, De Choudhury, Munmun   +3 more
doaj   +1 more source

Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial [PDF]

, 2014
Background: Only one-third of patients with depression respond fully to treatment with antidepressant medication. However, there is little robust evidence to guide the management of those whose symptoms are 'treatment resistant'.<p></p> ...
Abel, Anna, Barnes, Maria, Button, Katherine, Campbell, John, Carroll, Fran, Garland, Anne, Hollinghurst, Sandra, Jerrom, Bill, Kessler, David, Kuyken, Willem, Lewis, Glyn, Metcalfe, Chris, Morrison, Jill, Odondi, Lang'o, Owen-Smith, Amanda, Peters, Tim, Ridgway, Nicola, Sherlock, Sofie, Thomas, Laura, Turner, Katrina, Turner, Nicholas, Wiles, Nicola, Williams, Chris   +22 more
core   +3 more sources

Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review

Acta Dermato-Venereologica, 2017
There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory ...
Shirin Eskeland, Jon Anders Halvorsen, Lars Tanum   +2 more
doaj   +1 more source

‘Never change a winning team’: GPs’ perspectives on discontinuation of long-term antidepressants

Scandinavian Journal of Primary Health Care, 2021
Background Long-term antidepressant use, much longer than recommended by guidelines, can harm patients and generate unnecessary costs. Most antidepressants are prescribed by general practitioners (GPs) but it remains unclear why they do not discontinue ...
Van Leeuwen Ellen, Sibyl Anthierens, Mieke L. van Driel, An De Sutter, Evelien van den Branden, Thierry Christiaens   +5 more
doaj   +1 more source

Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. [PDF]

, 2004
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing.
Araki, Hiroaki, Gomita, Yutaka, Kitamura, Yoshihisa, Nagatani, Tadashi, Shibata, Kazuhiko, Takao, Katsuyuki   +5 more
core   +1 more source

Effects of Antidepressants on Sleep

Current Psychiatry Reports, 2017
Purpose of ReviewThe aim of this review article was to summarize recent publications on effects of antidepressants on sleep and to show that these effects not only depend on the kind of antidepressant drugs but are also related to the dose, the time of ...
A. Wichniak, A. Wierzbicka, Małgorzata Walęcka, W. Jernajczyk   +3 more
semanticscholar   +1 more source