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Tricyclic Antidepressants in Obsessive-Compulsive Disorder Antiobsessional or Antidepressant Agents?
The Journal of Nervous and Mental Disease, 1983The response to tricyclic antidepressants of eight obsessive-compulsive patients was assessed at pretreatment and at 4, 8, and 12 weeks of treatment, with the aim of delineating differential rates of improvement, or desynchrony, between the various symptoms. Change in obsessive-compulsive symptoms paralleled change in depression and anxiety, suggesting
Larry Michelson, Matig Mavissakalian
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Azetidine derivatives of tricyclic antidepressant agents
Journal of Medicinal Chemistry, 1979AbstractAuf dem im Formelschema skizzierten Wegen werden Azetidin‐Derivate wie (IV) und (X) dargestellt.
Piero Melloni +4 more
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ChemInform Abstract: 3‐ARYLQUINOLIZIDINES, POTENTIAL ANTIDEPRESSANT AGENTS
Chemischer Informationsdienst, 1975AbstractAus den Chinolizidin‐caF binolen (I) entstehen die Dehydratisierungsprodukte (II) und (III), deren Konformationen bestimmt werden.
Joseph Sam, M. E. Rogers
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Chapter 3 Antidepressant Agents
1987Publisher Summary The major concerns in current anti-depression therapy are delayed onset of activity, less than ideal efficacy, the importance of proper patient selection, and biochemical predictors of treatment response and side effects. There are various obstacles.
Daniel Luttinger, Dennis J. Hlasta
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Chapter 3. Antidepressant Agents
1989Publisher Summary This chapter discusses the several recent reviews that cover various aspects of depression and antidepressant research. The research on selective inhibitors of serotonin (5HT) uptake relative to their effects on the uptake of dopamine (DA) or norepinephrine (NE) has led to the successful development of selective serotonin reuptake ...
James Heym, J. L. Ives
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American Journal of Psychiatry, 1985
The authors explored the relationship between the antiobsessional and antidepressant effects of tricyclic drugs in primary obsessive-compulsive disorders. Study 1 consisted of a controlled 12-week trial with clomipramine (N = 7) and placebo (N = 5); study 2 analyzed the pooled data from 15 patients uniformly selected and treated with either ...
Matig Mavissakalian +3 more
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The authors explored the relationship between the antiobsessional and antidepressant effects of tricyclic drugs in primary obsessive-compulsive disorders. Study 1 consisted of a controlled 12-week trial with clomipramine (N = 7) and placebo (N = 5); study 2 analyzed the pooled data from 15 patients uniformly selected and treated with either ...
Matig Mavissakalian +3 more
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2016
Coumarin derivatives are well known as antidepressing agents. Several derivatives were analyzed for their potent activity and revealed their structure-activity relationship (SAR) for various substituents at different positions in the coumarin nucleus. Meta- and para-substituted phenyl groups at the C3 position of coumarin are significant for MAO enzyme
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Coumarin derivatives are well known as antidepressing agents. Several derivatives were analyzed for their potent activity and revealed their structure-activity relationship (SAR) for various substituents at different positions in the coumarin nucleus. Meta- and para-substituted phenyl groups at the C3 position of coumarin are significant for MAO enzyme
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Antidepressant-Antianxiety Agents
2012The complex title of this chapter reflects several basic points about this important class of medicines. They are now the most widely used psychotropic drugs, and even more in general medicine than in psychiatry [171, 384, 576]. Their origins in the 1950s were aimed specifically at a relatively complex group of depressive disorders prior to ...
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Stimulus properties of tiflucarbine: A novel antidepressant agent
Pharmacology Biochemistry and Behavior, 1990Tiflucarbine is a structurally novel antidepressant that binds at central serotonin (5-HT) binding sites. There is also evidence that this agent is both a 5-HT1 and a 5-HT2 agonist. To further characterize the serotonergic actions of this agent, tiflucarbine was evaluated in groups of rats trained to discriminate the 5-HT1A agonist 8-OH DPAT, the 5-HT2
Thomas Glaser +3 more
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AHR‐9377, a new antidepressant agent
Drug Development Research, 1985AbstractAHR‐9377 is a novel chemical structure with potential antidepressant activity. It was more potent than imipramine in mice, and equipotent with imipramine in rats in blocking tetrabenazine ptosis. Yohimbine toxicity in mice was potentiated by AHR‐9377 in doses less than those of imipramine.
Robert T. Ruckart +2 more
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