Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]
In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P +8 more
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Post-stroke depression modulation and in vivo antioxidant activity of gallic acid and its synthetic derivatives in a murine model system [PDF]
Gallic acid (3,4,5-trihydroxybenzoic acid, GA) is a plant secondary metabolite, which shows antioxidant activity and is commonly found in many plant-based foods and beverages.
Antoni Sureda +9 more
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Latent classes of nonresponders, rapid responders, and gradual responders in depressed outpatients receiving antidepressant medication and psychotherapy [PDF]
BackgroundWe used growth mixture modeling (GMM) to identify subsets of patients with qualitatively distinct symptom trajectories resulting from treatment. Existing studies have focused on 12-week antidepressant trials.
Bagby, Michael +5 more
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Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]
Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash +4 more
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Effectiveness of a recent topical sialogogue in the management of drug-induced xerostomia [PDF]
Objectives: Use of certain drugs is the most common aetiology of xerostomia. Systemic sialogogues provide a longer effect than topic ones, but also induce relevant side effects. Topical sialogogues, as malic acid, allow a safe use as they
Aguilar Salvatierra, Antonio +3 more
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Phytotherapy in zoo animals [PDF]
Phytotherapy is one of the oldest medical disciplines and was traditionally based on empiricism (Reichling et al., 2008). Nowadays, its use as an additional integral component of evidence based medicine is well accepted in human medicine (Finkelmann ...
Hoby, S., Walkenhorst, M., Wenker, C.
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Switch to hypomania induced by repetitive transcranial magnetic stimulation and partial sleep deprivation added to antidepressant: A case report [PDF]
Introduction. Bipolar depression is often unrecognized and difficult to treat because of two opposite problems: treatment resistance and risk of manic switch. Case report.
Ilić Tihomir V., Krstić Jelena
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Clinical relevance and treatment possibilities of bipolar rapid cycling [PDF]
Bipolar rapid cycling (RC) is defined as 4 or more affective episodes within 1 year. It has been postulated that RC is related to a poor response to lithium, to the same extent as mixed episodes or other atypical symptoms of the illness.
Amann, B. +3 more
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Insuficiência Hepática Aguda Induzida pela Trazodona e Diazepam [PDF]
Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the
Barroso, E +5 more
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Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C. +2 more
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